Antiepileptic drug toxicity: Definition and mechanism of action

E. Beghi, R. Di Mascio

Research output: Contribution to journalArticlepeer-review


A detailed review of the adverse reactions of anticonvulsants is given, focusing on the definitions of drug toxicity, sources of information, patterns of durg utilization, pharmacokinetic variables and different mechanisms of action. The information available in the literature provides a wide spectrum of drug toxicity with no attempt at a practical definition of the reported events. This favors uncertainty among practising physicians, who are led to use the individual items with different attitudes. Suggestions are given for the evaluation, prevention and treatment of anticonvulsant drug toxicity.

Original languageEnglish
Pages (from-to)209-222
Number of pages14
JournalItalian Journal of Neurological Sciences
Issue number2
Publication statusPublished - Apr 1986


  • Anticonvulsant drugs
  • side effects

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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