Drug treatment was gradually withdrawn in 231 adult patients (pts) seizure-free for 2 to 6 years. Our general data showed 64% and 72% of relapse respectively in pts followed for 3 and 5 years after complete AED suspension, but relapse rates differ widely among different types of epilepsy. Among generalized epilepsies recovery is more likely for idiopathic grand mal; among partial epilepsies recovery is possible for cryptogenic forms. The risk of relapse is highest in the first two years after withdrawal, but there is evidence of late relapses in partial epilepsies. Different significant prognostic factors were found in various epilepsies: age at onset in juvenile absence epilepsy, age at withdrawal in idopathic grand mal, evidence of lesions and family history of epilepsy in partial epilepsies.
|Translated title of the contribution||Antiepileptic drug withdrawal: When to risk|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Clinical Neurology