Antiepileptic drugs in Rett Syndrome

Maria Pintaudi, Maria Grazia Calevo, Aglaia Vignoli, Maria Giuseppina Baglietto, Yussef Hayek, Maria Traverso, Thea Giacomini, Lucio Giordano, Alessandra Renieri, Silvia Russo, Mariapaola Canevini, Edvige Veneselli

Research output: Contribution to journalArticle

Abstract

Purpose We investigated drugs most often used to treat epilepsy in Rett Syndrome and their efficacy in a large cohort of Italian patients. Methods This is a multi-centre retrospective study. Data of 165 Rett subjects were collected from the patients' files, and hospital charts. The efficacy of antiepileptic drugs (AEDs) was classified as follows: not effective; decrease in seizure frequency ≥50% for at least 6 months; seizure-free for at least 2 years. Phenotypic and genetic categorization of patients was performed and it was considered in AEDs efficacy evaluation. Results There were 130 epileptic patients.Sodium valproate (VPA) was the most commonly administered AED (44.3%) at seizure onset, followed by Carbamazepine (CBZ) (25.4%) and Phenobarbital (PB) (13%). Monotherapy was the first treatment option in most patients. VPA and CBZ proved to be equally effective in Rett patients who presented seizures within the typical age range (4-5 years), while Lamotrigine (LTG) was effective for patients in whom epilepsy started later. Overall, the frequency of side effects was low and the most often observed ones were restlessness and somnolence. Conclusion Our study suggests that LTG, VPA and CBZ can be used as drugs of first choice in Rett Syndrome. The association of four drugs should be avoided since it did not result in any significant clinical improvement.

Original languageEnglish
Pages (from-to)446-452
Number of pages7
JournalEuropean Journal of Paediatric Neurology
Volume19
Issue number4
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Rett Syndrome
Anticonvulsants
Carbamazepine
Valproic Acid
Seizures
Epilepsy
Pharmaceutical Preparations
Psychomotor Agitation
Drug Evaluation
Phenobarbital
Retrospective Studies

Keywords

  • AEDs
  • Efficacy
  • Epilepsy
  • Rett Syndrome
  • Therapy
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Pintaudi, M., Calevo, M. G., Vignoli, A., Baglietto, M. G., Hayek, Y., Traverso, M., ... Veneselli, E. (2015). Antiepileptic drugs in Rett Syndrome. European Journal of Paediatric Neurology, 19(4), 446-452. https://doi.org/10.1016/j.ejpn.2015.02.007

Antiepileptic drugs in Rett Syndrome. / Pintaudi, Maria; Calevo, Maria Grazia; Vignoli, Aglaia; Baglietto, Maria Giuseppina; Hayek, Yussef; Traverso, Maria; Giacomini, Thea; Giordano, Lucio; Renieri, Alessandra; Russo, Silvia; Canevini, Mariapaola; Veneselli, Edvige.

In: European Journal of Paediatric Neurology, Vol. 19, No. 4, 01.07.2015, p. 446-452.

Research output: Contribution to journalArticle

Pintaudi, M, Calevo, MG, Vignoli, A, Baglietto, MG, Hayek, Y, Traverso, M, Giacomini, T, Giordano, L, Renieri, A, Russo, S, Canevini, M & Veneselli, E 2015, 'Antiepileptic drugs in Rett Syndrome', European Journal of Paediatric Neurology, vol. 19, no. 4, pp. 446-452. https://doi.org/10.1016/j.ejpn.2015.02.007
Pintaudi M, Calevo MG, Vignoli A, Baglietto MG, Hayek Y, Traverso M et al. Antiepileptic drugs in Rett Syndrome. European Journal of Paediatric Neurology. 2015 Jul 1;19(4):446-452. https://doi.org/10.1016/j.ejpn.2015.02.007
Pintaudi, Maria ; Calevo, Maria Grazia ; Vignoli, Aglaia ; Baglietto, Maria Giuseppina ; Hayek, Yussef ; Traverso, Maria ; Giacomini, Thea ; Giordano, Lucio ; Renieri, Alessandra ; Russo, Silvia ; Canevini, Mariapaola ; Veneselli, Edvige. / Antiepileptic drugs in Rett Syndrome. In: European Journal of Paediatric Neurology. 2015 ; Vol. 19, No. 4. pp. 446-452.
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abstract = "Purpose We investigated drugs most often used to treat epilepsy in Rett Syndrome and their efficacy in a large cohort of Italian patients. Methods This is a multi-centre retrospective study. Data of 165 Rett subjects were collected from the patients' files, and hospital charts. The efficacy of antiepileptic drugs (AEDs) was classified as follows: not effective; decrease in seizure frequency ≥50{\%} for at least 6 months; seizure-free for at least 2 years. Phenotypic and genetic categorization of patients was performed and it was considered in AEDs efficacy evaluation. Results There were 130 epileptic patients.Sodium valproate (VPA) was the most commonly administered AED (44.3{\%}) at seizure onset, followed by Carbamazepine (CBZ) (25.4{\%}) and Phenobarbital (PB) (13{\%}). Monotherapy was the first treatment option in most patients. VPA and CBZ proved to be equally effective in Rett patients who presented seizures within the typical age range (4-5 years), while Lamotrigine (LTG) was effective for patients in whom epilepsy started later. Overall, the frequency of side effects was low and the most often observed ones were restlessness and somnolence. Conclusion Our study suggests that LTG, VPA and CBZ can be used as drugs of first choice in Rett Syndrome. The association of four drugs should be avoided since it did not result in any significant clinical improvement.",
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