Translated title of the contribution: Antiepileptic prophylaxis in head injured patients

A. De Santis, L. Bello, D. Spagnoli, E. Sganzerla

Research output: Contribution to journalArticlepeer-review


We present the results of a study aimed at verifying the efficacy of PB in preventing posttraumatic seizures in a series of head injured pts at risk for late seizures after a head injury. 97 head injured pts admitted at the Institute of Neurosurgery of the University of Milano from september 86 to December 88 have been selected for this study. All patients had or brain contusions (operated or not operated) or operated extracerebral blood collections or depressed fractures. 40 patients were medicated with PB which usually was withheld after 2 years. 57 did not receive any drug prophylaxis. All patients have been followed-up until April 92. Among the 57 not treated patients, 7 had seizures (12.2%), in all the first seizures appeared within two years from the head injury. Among the 40 patients who assumed PB prophylaxis, 6 had seizures (15%); after interruption of drug prophylaxis other 4 patients in this group had seizures. Up to now 10 pts who originally assumed PB prophylaxis had delayed posttraumatic seizures (25%). We therefore suggest that PB prophylaxis does not seem useful in preventing late posttraumatic seizures.

Translated title of the contributionAntiepileptic prophylaxis in head injured patients
Original languageItalian
Pages (from-to)305-306
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number79-80
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Clinical Neurology


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