TY - CHAP
T1 - Antiepileptic treatment in pregnant women
T2 - Morphological and behavioural effects
AU - Tomson, Torbjörn
AU - Battino, Dina
PY - 2011
Y1 - 2011
N2 - It is well established that children exposed to antiepileptic drugs (AEDs) in utero have an increased risk of adverse pregnancy outcomes including foetal growth retardation, major congenital malformations and impaired postnatal cognitive development. However, due to the significant maternal and foetal risks associated with uncontrolled epileptic seizures, AED treatment is generally maintained during pregnancy in the majority of women with active epilepsy. The prevalence of major malformations in children exposed to AEDs has ranged from 4 to 10%, 2-4 times higher than in the general population. More recent studies suggest a smaller increase in malformation rates. Malformation rates have consistently been higher in association with exposure to valproate than with carbamazepine and lamotrigine. Some prospective cohort studies also indicate reduced cognitive outcome in children exposed to valproate compared to carbamazepine and possibly lamotrigine. Information on pregnancy outcomes with newer generation AEDs other than lamotrigine are still insufficient.
AB - It is well established that children exposed to antiepileptic drugs (AEDs) in utero have an increased risk of adverse pregnancy outcomes including foetal growth retardation, major congenital malformations and impaired postnatal cognitive development. However, due to the significant maternal and foetal risks associated with uncontrolled epileptic seizures, AED treatment is generally maintained during pregnancy in the majority of women with active epilepsy. The prevalence of major malformations in children exposed to AEDs has ranged from 4 to 10%, 2-4 times higher than in the general population. More recent studies suggest a smaller increase in malformation rates. Malformation rates have consistently been higher in association with exposure to valproate than with carbamazepine and lamotrigine. Some prospective cohort studies also indicate reduced cognitive outcome in children exposed to valproate compared to carbamazepine and possibly lamotrigine. Information on pregnancy outcomes with newer generation AEDs other than lamotrigine are still insufficient.
KW - Antiepileptic drugs
KW - Congenital malformations
KW - Epilepsy
KW - Pregnancy
KW - Teratogenicity
UR - http://www.scopus.com/inward/record.url?scp=80054961464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054961464&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-20195-0_15
DO - 10.1007/978-3-642-20195-0_15
M3 - Chapter
C2 - 21882118
AN - SCOPUS:80054961464
SN - 9783642201943
VL - 205
T3 - Handbook of Experimental Pharmacology
SP - 295
EP - 315
BT - Handbook of Experimental Pharmacology
ER -