INDAGINE ELETTROFISIOLOGICA DELL'EFFICACIA TERAPEUTICA DEL VALPROATO DI MAGNESIO IN UN CAMPIONE DI SOGGETTI CON EPILESSIA GENERALIZZATA SECONDARIA: PRIMI RISULTATI

Translated title of the contribution: Antiepileptic trial with Mg-valproate: An electrophysiological evaluation of the results

P. Bergonzi, R. M. Colognola, M. Elia, R. Ferri, S. A. Musumeci

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ten subjects affected by secondarily generalized epilepsy underwent therapy with Mg-valproate and the results were evaluated by quantifying the spike epileptic activity on night sleep EEG recordings before and after therapy; epileptic spikes were counted per minute and per sleep stage. Mg-valproate was used either as add-on therapy or took the place of Na-valproate when this latter was already used. For this report four subjects only were evaluated; because of the reduced sample, we could apply the signs test in the evaluation of the results: a statistical significance (in the sense of a reduction of the epileptic activity after therapy with Mg-valproate) was shown only during S 1, while during WASO, S 2 and stage REM, only a trend was observed in the same direction (the reduction of the epileptic activity was observed in 3 subjects out of 4).

Translated title of the contributionAntiepileptic trial with Mg-valproate: An electrophysiological evaluation of the results
Original languageItalian
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Pages429-431
Number of pages3
Edition66-67
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Clinical Neurology

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