Antifungal and immunoadjuvant properties of fluconazole in mice immunosuppressed with morphine

Paolo Di Francesco, Roberta Gaziano, Ida A. Casalinuovo, Anna T. Palamara, Cartesio Favalli, Enrico Garaci

Research output: Contribution to journalArticle

Abstract

We investigated the efficacy of fluconazole on experimental disseminated candidiasis in mice immunocompromised by chronic morphine treatment. CD1 mice were severely immunosuppressed by repeated morphine administrations, i.e., subcutaneous (s.c.) injections of 75 mg/kg/day, 3 days before and 5 days after a systemic Candida albicans infection induced by intravenous administration of 1 x 106 fungal cells/mouse. Fluconazole (2.5 mg/kg, s.c., at 6, 24 and 48 h postinfection) was very effective in prolonging survival time of morphine-treated mice. Fluconazole treatment also promotes a recovery of killing activity of polymorphonuclear leukocyte cells suppressed by morphine administrations.

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalChemotherapy
Volume43
Issue number3
Publication statusPublished - May 1997

Keywords

  • Candida albicans
  • Fluconazole
  • Immunosuppression
  • Intracellular killing
  • Morphine
  • Polymorphonuclear leukocytes

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Antifungal and immunoadjuvant properties of fluconazole in mice immunosuppressed with morphine'. Together they form a unique fingerprint.

  • Cite this