Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant

Fiammetta Piersigilli; Cinzia Auriti; Iliana Bersani; Bianca Goffredo; Giuseppe Bianco; Imma Savarese; Andrea Dotta

doi:10.1097/INF.0000000000000116

Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant

Fiammetta Piersigilli, Cinzia Auriti, Iliana Bersani, Bianca Goffredo, Giuseppe Bianco, Imma Savarese, Andrea Dotta

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol 70% and micafungin sodium 5 mg/L was added to the therapy, and blood cultures became sterile.

Original language	English
Pages (from-to)	419-420
Number of pages	2
Journal	Pediatric Infectious Disease Journal
Volume	33
Issue number	4
DOIs	https://doi.org/10.1097/INF.0000000000000116
Publication status	Published - 2014

Keywords

Candidemia
Central venous catheter
Lock therapy
Micafungin
Neonate

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Infectious Diseases
Microbiology (medical)
Medicine(all)

Access to Document

10.1097/INF.0000000000000116

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abstract = "So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol 70% and micafungin sodium 5 mg/L was added to the therapy, and blood cultures became sterile.",

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AU - Auriti, Cinzia

AU - Bersani, Iliana

AU - Goffredo, Bianca

AU - Bianco, Giuseppe

AU - Savarese, Imma

AU - Dotta, Andrea

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KW - Central venous catheter

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KW - Micafungin

KW - Neonate

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