TY - JOUR
T1 - Antigen-Based Assays for the Identification of Influenza Virus and Respiratory Syncytial Virus
T2 - Why and How to Use Them in Pediatric Practice
AU - Principi, Nicola
AU - Esposito, Susanna
PY - 2009/12
Y1 - 2009/12
N2 - This article describes the clinical and socioeconomic relevance of influenza (IV) and respiratory syncytial virus (RSV) in pediatrics, the characteristics and limitations of currently available assays, and the impact of rapid diagnostic tests. This article shows that rapid tests for the detection and identification of IV and RSV in the respiratory secretions of infants and children are useful in the diagnosis of common, and possibly severe diseases, such as influenza and bronchiolitis. The tests' specificity and sensitivity make them most reliable when the prevalence of influenza or RSV infection is high, which suggests that their routine use should be restricted to the peak periods of viral circulation. The most recently marketed tests are similarly effective in identifying viruses, and so pediatricians should choose those that are less expensive, less time consuming, and easier to perform and to interpret.
AB - This article describes the clinical and socioeconomic relevance of influenza (IV) and respiratory syncytial virus (RSV) in pediatrics, the characteristics and limitations of currently available assays, and the impact of rapid diagnostic tests. This article shows that rapid tests for the detection and identification of IV and RSV in the respiratory secretions of infants and children are useful in the diagnosis of common, and possibly severe diseases, such as influenza and bronchiolitis. The tests' specificity and sensitivity make them most reliable when the prevalence of influenza or RSV infection is high, which suggests that their routine use should be restricted to the peak periods of viral circulation. The most recently marketed tests are similarly effective in identifying viruses, and so pediatricians should choose those that are less expensive, less time consuming, and easier to perform and to interpret.
KW - Antigen-based assay
KW - Children
KW - Influenza
KW - Influenza virus
KW - Pediatrics
KW - Respiratory syncytial virus
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U2 - 10.1016/j.cll.2009.07.006
DO - 10.1016/j.cll.2009.07.006
M3 - Article
C2 - 19892226
AN - SCOPUS:70350512606
VL - 29
SP - 649
EP - 660
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
SN - 0272-2712
IS - 4
ER -