Antigen-binding cells from auricular lymph nodes of rabbits skin sensitized with DNFB were detected by rosette formation. Electron microscopy studies on the morphology of the RFC showed that the rosettes were formed around lymphoblasts and small lymphocytes only. Inhibition experiments of RFCs by anti-allo-type and anti-class specific antisera indicated that the receptors of the RFC were immunoglobulin, predominantly of the IgM class. The lack of antibody production, as shown by the absence of plaque-forming cells in the lymph nodes would suggest that the RFCs are possibly the cells involved in a delayed hypersensitivity response. However, the lack of membrane antigenic markers for T and B cells in rabbits makes the interpretation of these results difficult.
ASJC Scopus subject areas
- Immunology and Allergy