Antigen dependent and independent mechanisms that sustain serum antibody levels

Elisabetta Traggiai, Roberto Puzone, Antonio Lanzavecchia

Research output: Contribution to journalArticlepeer-review

Abstract

In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) poyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relative contribution of antigen induced short- and long-lived plasma cells versus polyclonal activation of all memory B cells. Antigenic boost sustains high levels of serum antibodies only for a few months, while polyclonal activation sustains low levels of protective antibodies for a human lifetime.

Original languageEnglish
JournalVaccine
Volume21
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Antibodies
  • Plasma cells
  • Serological memory

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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