Antigen-dependent mast cell differentiation in vitro

P. Comoglio

Research output: Contribution to journalArticlepeer-review


Organ cultures of 17-day-old chick embryo spleens were made in the presence of a soluble antigen (bovine serum albumin). After 24 h of incubation with 10 μ/ml of antigen, mast cells (MC) start to differentiate from some unknown precursor cells, and their total number increased progressively till 72 h. No mitoses were observed in MCs during the whole period of incubation. Histochemical and ultrastructural evidence of MC differentiation is presented and the possible inductive mechanisms are briefly discussed.

Original languageEnglish
Pages (from-to)404-408
Number of pages5
JournalExperimental Cell Research
Issue number2
Publication statusPublished - 1972

ASJC Scopus subject areas

  • Cell Biology


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