Antigen-dependent mast cell differentiation in vitro

P. Comoglio

doi:10.1016/0014-4827(72)90008-0

Antigen-dependent mast cell differentiation in vitro

P. Comoglio

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Organ cultures of 17-day-old chick embryo spleens were made in the presence of a soluble antigen (bovine serum albumin). After 24 h of incubation with 10 μ/ml of antigen, mast cells (MC) start to differentiate from some unknown precursor cells, and their total number increased progressively till 72 h. No mitoses were observed in MCs during the whole period of incubation. Histochemical and ultrastructural evidence of MC differentiation is presented and the possible inductive mechanisms are briefly discussed.

Original language	English
Pages (from-to)	404-408
Number of pages	5
Journal	Experimental Cell Research
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/0014-4827(72)90008-0
Publication status	Published - 1972

ASJC Scopus subject areas

Cell Biology

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10.1016/0014-4827(72)90008-0

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title = "Antigen-dependent mast cell differentiation in vitro",

abstract = "Organ cultures of 17-day-old chick embryo spleens were made in the presence of a soluble antigen (bovine serum albumin). After 24 h of incubation with 10 μ/ml of antigen, mast cells (MC) start to differentiate from some unknown precursor cells, and their total number increased progressively till 72 h. No mitoses were observed in MCs during the whole period of incubation. Histochemical and ultrastructural evidence of MC differentiation is presented and the possible inductive mechanisms are briefly discussed.",

author = "P. Comoglio",

year = "1972",

doi = "10.1016/0014-4827(72)90008-0",

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AB - Organ cultures of 17-day-old chick embryo spleens were made in the presence of a soluble antigen (bovine serum albumin). After 24 h of incubation with 10 μ/ml of antigen, mast cells (MC) start to differentiate from some unknown precursor cells, and their total number increased progressively till 72 h. No mitoses were observed in MCs during the whole period of incubation. Histochemical and ultrastructural evidence of MC differentiation is presented and the possible inductive mechanisms are briefly discussed.

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Antigen-dependent mast cell differentiation in vitro

Abstract

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