Antigen-indipendent peripheral immune. Activation precedes clinical and mri evidence of disease activity in MS

G. Martino; F. Grohovaz; E. Brambilla; E. Clementi

Antigen-indipendent peripheral immune. Activation precedes clinical and mri evidence of disease activity in MS

G. Martino, F. Grohovaz, E. Brambilla, E. Clementi

Research output: Contribution to journal › Article › peer-review

Abstract

Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen-specific autoreactive T cells and a multitude of pathogenic non-specific lymphocytes. We report that in patients with MS the combined action of interferon-y, tumor necrosis factor CC , interleukin (IL)-2 and IL-6 leads to the activation of the majority of peripheral T cells (mainly CD4memory) by promoting a persistent intracellular calcium increase via two indipendent signaling pathways. The activation of these pathways, which is indipendent from myelin antigens, precedes by two weeks phase? of diseip a

Original language	English
Pages (from-to)	77
Number of pages	1
Journal	Italian Journal of Neurological Sciences
Volume	18
Issue number	4
Publication status	Published - 1997

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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abstract = "Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen-specific autoreactive T cells and a multitude of pathogenic non-specific lymphocytes. We report that in patients with MS the combined action of interferon-y, tumor necrosis factor CC , interleukin (IL)-2 and IL-6 leads to the activation of the majority of peripheral T cells (mainly CD4memory) by promoting a persistent intracellular calcium increase via two indipendent signaling pathways. The activation of these pathways, which is indipendent from myelin antigens, precedes by two weeks phase? of diseip a",

author = "G. Martino and F. Grohovaz and E. Brambilla and E. Clementi",

year = "1997",

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pages = "77",

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AU - Martino, G.

AU - Grohovaz, F.

AU - Brambilla, E.

AU - Clementi, E.

PY - 1997

Y1 - 1997

N2 - Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen-specific autoreactive T cells and a multitude of pathogenic non-specific lymphocytes. We report that in patients with MS the combined action of interferon-y, tumor necrosis factor CC , interleukin (IL)-2 and IL-6 leads to the activation of the majority of peripheral T cells (mainly CD4memory) by promoting a persistent intracellular calcium increase via two indipendent signaling pathways. The activation of these pathways, which is indipendent from myelin antigens, precedes by two weeks phase? of diseip a

AB - Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen-specific autoreactive T cells and a multitude of pathogenic non-specific lymphocytes. We report that in patients with MS the combined action of interferon-y, tumor necrosis factor CC , interleukin (IL)-2 and IL-6 leads to the activation of the majority of peripheral T cells (mainly CD4memory) by promoting a persistent intracellular calcium increase via two indipendent signaling pathways. The activation of these pathways, which is indipendent from myelin antigens, precedes by two weeks phase? of diseip a

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