Abstract
Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen-specific autoreactive T cells and a multitude of pathogenic non-specific lymphocytes. We report that in patients with MS the combined action of interferon-y, tumor necrosis factor CC , interleukin (IL)-2 and IL-6 leads to the activation of the majority of peripheral T cells (mainly CD4memory) by promoting a persistent intracellular calcium increase via two indipendent signaling pathways. The activation of these pathways, which is indipendent from myelin antigens, precedes by two weeks phase? of diseip a
Original language | English |
---|---|
Pages (from-to) | 77 |
Number of pages | 1 |
Journal | Italian Journal of Neurological Sciences |
Volume | 18 |
Issue number | 4 |
Publication status | Published - 1997 |
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology