Antigen-indipendent peripheral immune. Activation precedes clinical and mri evidence of disease activity in MS

G. Martino, F. Grohovaz, E. Brambilla, E. Clementi

Research output: Contribution to journalArticlepeer-review

Abstract

Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen-specific autoreactive T cells and a multitude of pathogenic non-specific lymphocytes. We report that in patients with MS the combined action of interferon-y, tumor necrosis factor CC , interleukin (IL)-2 and IL-6 leads to the activation of the majority of peripheral T cells (mainly CD4memory) by promoting a persistent intracellular calcium increase via two indipendent signaling pathways. The activation of these pathways, which is indipendent from myelin antigens, precedes by two weeks phase? of diseip a

Original languageEnglish
Pages (from-to)77
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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