Antigenic expression changes occurring in adriamycin resistant MCF-7 mammary carcinoma cells

M. Nuti, G. Zupi, I. D'Agnano, V. Turchi, A. Candiloro, L. Frati

Research output: Contribution to journalArticle

Abstract

The antigenic phenotypic repertoire of MGF-7 human breast carcinoma cell line variants that display different sensitivity to adriamycin (Adr) was analyzed using monoclonal antibodies (MoAbs) recognizing five different tumor associated antigens (TAAs) and the external domain of the epidermal growth factor receptor (EGF-R). ELISA and cytofluorimetry determinations were used and results indicate a diminished expression of one antigenic determinant of the carcinoembryonic antigen (CEA) molecule, the disappearance of all the other TAAs and the de novo expression of the EGF-R in the MCF-7 AdrR (IC50/Adr:10 uM). Treatment with recombinant alfa-Interferon (alfa-IFN) did not enhance antigenic expression in MCF-7 AdrR cells.

Original languageEnglish
Pages (from-to)1225-1230
Number of pages6
JournalAnticancer Research
Volume11
Issue number3
Publication statusPublished - 1991

Keywords

  • breast cancer
  • drug resistance
  • TAA expression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Nuti, M., Zupi, G., D'Agnano, I., Turchi, V., Candiloro, A., & Frati, L. (1991). Antigenic expression changes occurring in adriamycin resistant MCF-7 mammary carcinoma cells. Anticancer Research, 11(3), 1225-1230.