Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18x106 U recombinant IFN-α. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-α.
|Number of pages||3|
|Journal||British Journal of Cancer|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Cancer Research