Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino.

Translated title of the contribution: Antigliadin antibodies (AGA) in the various stages of celiac disease in children

G. Bottaro, A. Sciacca, P. Failla, M. Cagnina, M. C. Di Pietro, O. Ricca, M. L. Iudica, N. Castiglione, R. Patanè

Research output: Contribution to journalArticle

Abstract

Antigliadin antibodies (AGA), both IgA and IgG, were studied in the serum of 84 coeliac children during the various stage (Diagnosis, GFD, Challenge) and in 29 healthy children, with a micro-ELISA technique. The results demonstrated the presence of AGA in the serum of coeliac children and a different behaviour between the two Ig-classes in the various stages of the disease. During acute phase both classes were present at high titre. When gluten was withdrawal from the diet, while the titre of IgA fell rapidly since the first month, the IgG titre decreased slowly and raised the normal limits after six months. If the children didn't observe a corrected GFD, the serum AGA titres remained at high levels. During challenge, while IgG raised since the early days, IgA titres raised later, when the intestinal damage became important. The explanation of this different behaviour could be that AGA-IgA are derived from gut mucosa, on the contrary AGA-IgG are not synthesised in the intestine. We believe that serum AGA seem to be good markers of the immune reaction in the intestine triggered by gluten. Furthermore we conclude that the assay of AGA in the serum of coeliac patients is: 1) high sensible and specific method; 2) the most important screening test for intestinal biopsy; 3) the most important test for diagnosis and follow-up of CD; 4) the test which could substitute 1 or 2 intestinal biopsies of the ESPGAN protocol.

Original languageItalian
Pages (from-to)409-413
Number of pages5
JournalPediatria Medica e Chirurgica
Volume10
Issue number4
Publication statusPublished - Jul 1988

Fingerprint

Celiac Disease
Antibodies
Immunoglobulin A
Immunoglobulin G
Abdomen
Serum
Glutens
Intestines
Biopsy
Mucous Membrane
Biomarkers
Enzyme-Linked Immunosorbent Assay
Diet

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bottaro, G., Sciacca, A., Failla, P., Cagnina, M., Di Pietro, M. C., Ricca, O., ... Patanè, R. (1988). Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino. Pediatria Medica e Chirurgica, 10(4), 409-413.

Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino. / Bottaro, G.; Sciacca, A.; Failla, P.; Cagnina, M.; Di Pietro, M. C.; Ricca, O.; Iudica, M. L.; Castiglione, N.; Patanè, R.

In: Pediatria Medica e Chirurgica, Vol. 10, No. 4, 07.1988, p. 409-413.

Research output: Contribution to journalArticle

Bottaro, G, Sciacca, A, Failla, P, Cagnina, M, Di Pietro, MC, Ricca, O, Iudica, ML, Castiglione, N & Patanè, R 1988, 'Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino.', Pediatria Medica e Chirurgica, vol. 10, no. 4, pp. 409-413.
Bottaro G, Sciacca A, Failla P, Cagnina M, Di Pietro MC, Ricca O et al. Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino. Pediatria Medica e Chirurgica. 1988 Jul;10(4):409-413.
Bottaro, G. ; Sciacca, A. ; Failla, P. ; Cagnina, M. ; Di Pietro, M. C. ; Ricca, O. ; Iudica, M. L. ; Castiglione, N. ; Patanè, R. / Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino. In: Pediatria Medica e Chirurgica. 1988 ; Vol. 10, No. 4. pp. 409-413.
@article{e88c0ec54b084601a4af7ca983719d41,
title = "Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino.",
abstract = "Antigliadin antibodies (AGA), both IgA and IgG, were studied in the serum of 84 coeliac children during the various stage (Diagnosis, GFD, Challenge) and in 29 healthy children, with a micro-ELISA technique. The results demonstrated the presence of AGA in the serum of coeliac children and a different behaviour between the two Ig-classes in the various stages of the disease. During acute phase both classes were present at high titre. When gluten was withdrawal from the diet, while the titre of IgA fell rapidly since the first month, the IgG titre decreased slowly and raised the normal limits after six months. If the children didn't observe a corrected GFD, the serum AGA titres remained at high levels. During challenge, while IgG raised since the early days, IgA titres raised later, when the intestinal damage became important. The explanation of this different behaviour could be that AGA-IgA are derived from gut mucosa, on the contrary AGA-IgG are not synthesised in the intestine. We believe that serum AGA seem to be good markers of the immune reaction in the intestine triggered by gluten. Furthermore we conclude that the assay of AGA in the serum of coeliac patients is: 1) high sensible and specific method; 2) the most important screening test for intestinal biopsy; 3) the most important test for diagnosis and follow-up of CD; 4) the test which could substitute 1 or 2 intestinal biopsies of the ESPGAN protocol.",
author = "G. Bottaro and A. Sciacca and P. Failla and M. Cagnina and {Di Pietro}, {M. C.} and O. Ricca and Iudica, {M. L.} and N. Castiglione and R. Patan{\`e}",
year = "1988",
month = "7",
language = "Italian",
volume = "10",
pages = "409--413",
journal = "Pediatria Medica e Chirurgica",
issn = "0391-5387",
publisher = "Vicenza Pediatria Medica E Chirurgica",
number = "4",

}

TY - JOUR

T1 - Gli anticorpi antigliadina (AGA) nelle varie fasi della malattia celiaca del bambino.

AU - Bottaro, G.

AU - Sciacca, A.

AU - Failla, P.

AU - Cagnina, M.

AU - Di Pietro, M. C.

AU - Ricca, O.

AU - Iudica, M. L.

AU - Castiglione, N.

AU - Patanè, R.

PY - 1988/7

Y1 - 1988/7

N2 - Antigliadin antibodies (AGA), both IgA and IgG, were studied in the serum of 84 coeliac children during the various stage (Diagnosis, GFD, Challenge) and in 29 healthy children, with a micro-ELISA technique. The results demonstrated the presence of AGA in the serum of coeliac children and a different behaviour between the two Ig-classes in the various stages of the disease. During acute phase both classes were present at high titre. When gluten was withdrawal from the diet, while the titre of IgA fell rapidly since the first month, the IgG titre decreased slowly and raised the normal limits after six months. If the children didn't observe a corrected GFD, the serum AGA titres remained at high levels. During challenge, while IgG raised since the early days, IgA titres raised later, when the intestinal damage became important. The explanation of this different behaviour could be that AGA-IgA are derived from gut mucosa, on the contrary AGA-IgG are not synthesised in the intestine. We believe that serum AGA seem to be good markers of the immune reaction in the intestine triggered by gluten. Furthermore we conclude that the assay of AGA in the serum of coeliac patients is: 1) high sensible and specific method; 2) the most important screening test for intestinal biopsy; 3) the most important test for diagnosis and follow-up of CD; 4) the test which could substitute 1 or 2 intestinal biopsies of the ESPGAN protocol.

AB - Antigliadin antibodies (AGA), both IgA and IgG, were studied in the serum of 84 coeliac children during the various stage (Diagnosis, GFD, Challenge) and in 29 healthy children, with a micro-ELISA technique. The results demonstrated the presence of AGA in the serum of coeliac children and a different behaviour between the two Ig-classes in the various stages of the disease. During acute phase both classes were present at high titre. When gluten was withdrawal from the diet, while the titre of IgA fell rapidly since the first month, the IgG titre decreased slowly and raised the normal limits after six months. If the children didn't observe a corrected GFD, the serum AGA titres remained at high levels. During challenge, while IgG raised since the early days, IgA titres raised later, when the intestinal damage became important. The explanation of this different behaviour could be that AGA-IgA are derived from gut mucosa, on the contrary AGA-IgG are not synthesised in the intestine. We believe that serum AGA seem to be good markers of the immune reaction in the intestine triggered by gluten. Furthermore we conclude that the assay of AGA in the serum of coeliac patients is: 1) high sensible and specific method; 2) the most important screening test for intestinal biopsy; 3) the most important test for diagnosis and follow-up of CD; 4) the test which could substitute 1 or 2 intestinal biopsies of the ESPGAN protocol.

UR - http://www.scopus.com/inward/record.url?scp=0024051994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024051994&partnerID=8YFLogxK

M3 - Articolo

C2 - 3231548

AN - SCOPUS:0024051994

VL - 10

SP - 409

EP - 413

JO - Pediatria Medica e Chirurgica

JF - Pediatria Medica e Chirurgica

SN - 0391-5387

IS - 4

ER -