Abstract
Cysteinyl leukotrienes (CysLTs) are a key element of allergic inflammation. Thus, the antagonism of CysLTs appears a potential target of allergic rhinitis management. Antileukotrienes and antihistamines combined showed a synergistic effect in treating seasonal allergic rhinitis (SAR). This double blind, parallel group, randomized study aimed at evaluating the clinical and anti-inflammatory effects exerted by two combinations of antihistamine plus antileukotriene in patients with SAR and mild intermittent asthma. Thirty patients were treated with montelukast added to cetirizine (M-C group) or desloratadine (M-D group) for 2 weeks. The visits, including spirometry, nasal scraping and lavage, were performed in all subjects before and directly after the treatment. Evaluation parameters were: i) nasal symptoms, ii) number of eosinophils and neutrophils, and iii) IL5 and IL8 levels. Both combinations significantly reduced: nasal symptoms (p
Original language | English |
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Pages (from-to) | 67-72 |
Number of pages | 6 |
Journal | European Annals of Allergy and Clinical Immunology |
Volume | 36 |
Issue number | 2 |
Publication status | Published - Feb 2004 |
Keywords
- Cetirizine
- Cytokines
- Desloratadine
- Inflammatory cells
- Montelukast
- Seasonal allergic rhinitis
ASJC Scopus subject areas
- Immunology and Allergy