Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: Histamine and leukotriene antagonism

Giorgio Ciprandi, Maria Angela Tosca, Manlio Milanese, Guido Schenone, Vittorio Ricca

Research output: Contribution to journalArticle


Cysteinyl leukotrienes (CysLTs) are a key element of allergic inflammation. Thus, the antagonism of CysLTs appears a potential target of allergic rhinitis management. Antileukotrienes and antihistamines combined showed a synergistic effect in treating seasonal allergic rhinitis (SAR). This double blind, parallel group, randomized study aimed at evaluating the clinical and anti-inflammatory effects exerted by two combinations of antihistamine plus antileukotriene in patients with SAR and mild intermittent asthma. Thirty patients were treated with montelukast added to cetirizine (M-C group) or desloratadine (M-D group) for 2 weeks. The visits, including spirometry, nasal scraping and lavage, were performed in all subjects before and directly after the treatment. Evaluation parameters were: i) nasal symptoms, ii) number of eosinophils and neutrophils, and iii) IL5 and IL8 levels. Both combinations significantly reduced: nasal symptoms (p

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalEuropean Annals of Allergy and Clinical Immunology
Issue number2
Publication statusPublished - Feb 2004



  • Cetirizine
  • Cytokines
  • Desloratadine
  • Inflammatory cells
  • Montelukast
  • Seasonal allergic rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy

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