Antihistaminics H1 and H2 do not modify the human prolactin response to arginine infusion and insulin hypoglycemia

A. E. Pontiroli, R. R. Gala, G. Pellicciotta

Research output: Contribution to journalArticlepeer-review

Abstract

Healthy adult subjects of both sexes volunteered for our studies. Sixteen subjects (10 M + 6 F) underwent an arginine infusion test (25 g in 30 min) in basal conditions and following the administration of H1 antagonists in 8 subjects (meclastine, 3 mg/day for 3 days p.o. plus 1 mg 1 h before the second test, or dexchlorpheniramine, 10 mg, infused i.v. from -30 to 60 min) or after repeated cimetidine administration in 8 subjects (1.0 g/day p.o. for 5 days plus 0.4 g 1 h before the second test). Similarly, fourteen subjects (9 M + 5 F) underwent an insulin hypoglycemia test (0.1 U/Kg b.w.) in basal conditions and following treatment with H1 antagonists (7 subjects) or H2 antagonists (7 subjects). Plasma PRL level were determined in duplicate by radioimmunoassay (Gala, Singhakowinta and Brennan 1975). Arginine elicited in all subjects a slight but significant PRL release which was not modified by either H1 or H2 antagonists. Similarly, insulin hypoglycemia elicited a clear PRL response, unaffected by either H1 or H2 antagonists.

Original languageEnglish
Pages (from-to)557-558
Number of pages2
JournalHormone and Metabolic Research
Volume12
Issue number10
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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