Abstract
The antihypertensive effect of amiodarone was investigated in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The SHR and WKY were treated with amiodarone (1 mg/mL PO) or tap water (control) for 20 weeks. The indirect arterial pressure (AP) was monitored weekly using the tail-cuff method. At the end of the 20th week, the direct AP was measured, and the systolic AP and pulse interval time series were submitted to autoregressive spectral analysis. In addition, cardiac baroreflex sensitivity and left ventricular weight were evaluated as well. The indirect AP was reduced 1 week after the beginning of amiodarone treatment. The direct mean AP and pulse interval were, respectively, 135+/-8 mm Hg and 191+/-3 ms in SHR treated with amiodarone (187+/-8 mm Hg and 156+/-7 ms in control SHR, P
| Original language | English |
|---|---|
| Pages (from-to) | 597-601 |
| Number of pages | 5 |
| Journal | Hypertension |
| Volume | 38 |
| Issue number | 3 Pt 2 |
| Publication status | Published - Sep 2001 |
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ASJC Scopus subject areas
- Internal Medicine
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Antihypertensive action of amiodarone in spontaneously hypertensive rats. / Dias Da Silva, V. J.; Cavalcante Viana, P. C.; de Melo Alves, R.; Salgado, H. C.; Montano, N.; Fazan, R.
In: Hypertension, Vol. 38, No. 3 Pt 2, 09.2001, p. 597-601.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antihypertensive action of amiodarone in spontaneously hypertensive rats.
AU - Dias Da Silva, V. J.
AU - Cavalcante Viana, P. C.
AU - de Melo Alves, R.
AU - Salgado, H. C.
AU - Montano, N.
AU - Fazan, R.
PY - 2001/9
Y1 - 2001/9
N2 - The antihypertensive effect of amiodarone was investigated in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The SHR and WKY were treated with amiodarone (1 mg/mL PO) or tap water (control) for 20 weeks. The indirect arterial pressure (AP) was monitored weekly using the tail-cuff method. At the end of the 20th week, the direct AP was measured, and the systolic AP and pulse interval time series were submitted to autoregressive spectral analysis. In addition, cardiac baroreflex sensitivity and left ventricular weight were evaluated as well. The indirect AP was reduced 1 week after the beginning of amiodarone treatment. The direct mean AP and pulse interval were, respectively, 135+/-8 mm Hg and 191+/-3 ms in SHR treated with amiodarone (187+/-8 mm Hg and 156+/-7 ms in control SHR, P
AB - The antihypertensive effect of amiodarone was investigated in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The SHR and WKY were treated with amiodarone (1 mg/mL PO) or tap water (control) for 20 weeks. The indirect arterial pressure (AP) was monitored weekly using the tail-cuff method. At the end of the 20th week, the direct AP was measured, and the systolic AP and pulse interval time series were submitted to autoregressive spectral analysis. In addition, cardiac baroreflex sensitivity and left ventricular weight were evaluated as well. The indirect AP was reduced 1 week after the beginning of amiodarone treatment. The direct mean AP and pulse interval were, respectively, 135+/-8 mm Hg and 191+/-3 ms in SHR treated with amiodarone (187+/-8 mm Hg and 156+/-7 ms in control SHR, P
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UR - http://www.scopus.com/inward/citedby.url?scp=0035463113&partnerID=8YFLogxK
M3 - Article
C2 - 11566938
AN - SCOPUS:0035463113
VL - 38
SP - 597
EP - 601
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 3 Pt 2
ER -