Antihypertensive action of amiodarone in spontaneously hypertensive rats.

V. J. Dias Da Silva, P. C. Cavalcante Viana, R. de Melo Alves, H. C. Salgado, N. Montano, R. Fazan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The antihypertensive effect of amiodarone was investigated in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The SHR and WKY were treated with amiodarone (1 mg/mL PO) or tap water (control) for 20 weeks. The indirect arterial pressure (AP) was monitored weekly using the tail-cuff method. At the end of the 20th week, the direct AP was measured, and the systolic AP and pulse interval time series were submitted to autoregressive spectral analysis. In addition, cardiac baroreflex sensitivity and left ventricular weight were evaluated as well. The indirect AP was reduced 1 week after the beginning of amiodarone treatment. The direct mean AP and pulse interval were, respectively, 135+/-8 mm Hg and 191+/-3 ms in SHR treated with amiodarone (187+/-8 mm Hg and 156+/-7 ms in control SHR, P

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalHypertension
Volume38
Issue number3 Pt 2
Publication statusPublished - Sep 2001

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Amiodarone
Inbred SHR Rats
Antihypertensive Agents
Arterial Pressure
Inbred WKY Rats
Baroreflex
Tail
Blood Pressure
Weights and Measures
Water

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Dias Da Silva, V. J., Cavalcante Viana, P. C., de Melo Alves, R., Salgado, H. C., Montano, N., & Fazan, R. (2001). Antihypertensive action of amiodarone in spontaneously hypertensive rats. Hypertension, 38(3 Pt 2), 597-601.

Antihypertensive action of amiodarone in spontaneously hypertensive rats. / Dias Da Silva, V. J.; Cavalcante Viana, P. C.; de Melo Alves, R.; Salgado, H. C.; Montano, N.; Fazan, R.

In: Hypertension, Vol. 38, No. 3 Pt 2, 09.2001, p. 597-601.

Research output: Contribution to journalArticle

Dias Da Silva, VJ, Cavalcante Viana, PC, de Melo Alves, R, Salgado, HC, Montano, N & Fazan, R 2001, 'Antihypertensive action of amiodarone in spontaneously hypertensive rats.', Hypertension, vol. 38, no. 3 Pt 2, pp. 597-601.
Dias Da Silva VJ, Cavalcante Viana PC, de Melo Alves R, Salgado HC, Montano N, Fazan R. Antihypertensive action of amiodarone in spontaneously hypertensive rats. Hypertension. 2001 Sep;38(3 Pt 2):597-601.
Dias Da Silva, V. J. ; Cavalcante Viana, P. C. ; de Melo Alves, R. ; Salgado, H. C. ; Montano, N. ; Fazan, R. / Antihypertensive action of amiodarone in spontaneously hypertensive rats. In: Hypertension. 2001 ; Vol. 38, No. 3 Pt 2. pp. 597-601.
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