Antihypertensive action of amiodarone in spontaneously hypertensive rats.

V. J. Dias Da Silva; P. C. Cavalcante Viana; R. de Melo Alves; H. C. Salgado; N. Montano; R. Fazan

Antihypertensive action of amiodarone in spontaneously hypertensive rats.

V. J. Dias Da Silva, P. C. Cavalcante Viana, R. de Melo Alves, H. C. Salgado, N. Montano, R. Fazan

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

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Abstract

The antihypertensive effect of amiodarone was investigated in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The SHR and WKY were treated with amiodarone (1 mg/mL PO) or tap water (control) for 20 weeks. The indirect arterial pressure (AP) was monitored weekly using the tail-cuff method. At the end of the 20th week, the direct AP was measured, and the systolic AP and pulse interval time series were submitted to autoregressive spectral analysis. In addition, cardiac baroreflex sensitivity and left ventricular weight were evaluated as well. The indirect AP was reduced 1 week after the beginning of amiodarone treatment. The direct mean AP and pulse interval were, respectively, 135+/-8 mm Hg and 191+/-3 ms in SHR treated with amiodarone (187+/-8 mm Hg and 156+/-7 ms in control SHR, P

Original language	English
Pages (from-to)	597-601
Number of pages	5
Journal	Hypertension
Volume	38
Issue number	3 Pt 2
Publication status	Published - Sep 2001

ASJC Scopus subject areas

Internal Medicine

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Dias Da Silva, V. J., Cavalcante Viana, P. C., de Melo Alves, R., Salgado, H. C., Montano, N., & Fazan, R. (2001). Antihypertensive action of amiodarone in spontaneously hypertensive rats. Hypertension, 38(3 Pt 2), 597-601.

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AU - Dias Da Silva, V. J.

AU - Cavalcante Viana, P. C.

AU - de Melo Alves, R.

AU - Salgado, H. C.

AU - Montano, N.

AU - Fazan, R.

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AB - The antihypertensive effect of amiodarone was investigated in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The SHR and WKY were treated with amiodarone (1 mg/mL PO) or tap water (control) for 20 weeks. The indirect arterial pressure (AP) was monitored weekly using the tail-cuff method. At the end of the 20th week, the direct AP was measured, and the systolic AP and pulse interval time series were submitted to autoregressive spectral analysis. In addition, cardiac baroreflex sensitivity and left ventricular weight were evaluated as well. The indirect AP was reduced 1 week after the beginning of amiodarone treatment. The direct mean AP and pulse interval were, respectively, 135+/-8 mm Hg and 191+/-3 ms in SHR treated with amiodarone (187+/-8 mm Hg and 156+/-7 ms in control SHR, P

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