Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension

M. Volpe, G. Odell, H. D. Kleinert, M. J. Camargot, J. H. Laragh, J. A. Lewicki, T. Maack, E. D. Vaughan, S. A. Atlas

Research output: Contribution to journalArticle

Abstract

A 24-amino acid residue synthetic atrial natriuretic factor (ANF) antagonizes angiotensin II-induced vascular contractility and aldosterone production in isolated blood vessels and adrenal cells, respectively. To determine the significance of these effects in vivo, the blood pressure and aldosterone responses to synthetic ANF were evaluated in rats with two-kidney, one clip hypertension (n = 5) and in sham-operated controls (n = 4). In the latter, ANF caused a slight fall in mean blood pressure (-7 ± 3%) and inconsistent changes in plasma renin and aldosterone. In hypertensive rats, ANF decreased blood pressure by 31 ± 7 mmHg (17 ± 3%), comparable to the effect of the angiotensin antagonist saralasin (31 ± 4 mmHg). Plasma renin activity increased from 48 ± 15 to 79 ± 23 ng/ml/h. Despite this, ANF caused marked suppression of plasma aldosterone (from 97 ± 28 to 20 ± 8.9 ng/100 ml). These results show that ANF can exert potent antihypertensive and aldosterone-lowering effects in vivo, at least when the renin-angiotensin system is stimulated.

Original languageEnglish
Pages (from-to)313-315
Number of pages3
JournalJournal of Hypertension
Volume2
Issue numberSUPPL. 3
Publication statusPublished - 1984

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Renovascular Hypertension
Atrial Natriuretic Factor
Aldosterone
Renin
Antihypertensive Agents
Blood Pressure
Blood Vessels
Saralasin
Angiotensins
Renin-Angiotensin System
Surgical Instruments
Angiotensin II
Hypertension
Kidney
Amino Acids

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Volpe, M., Odell, G., Kleinert, H. D., Camargot, M. J., Laragh, J. H., Lewicki, J. A., ... Atlas, S. A. (1984). Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension. Journal of Hypertension, 2(SUPPL. 3), 313-315.

Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension. / Volpe, M.; Odell, G.; Kleinert, H. D.; Camargot, M. J.; Laragh, J. H.; Lewicki, J. A.; Maack, T.; Vaughan, E. D.; Atlas, S. A.

In: Journal of Hypertension, Vol. 2, No. SUPPL. 3, 1984, p. 313-315.

Research output: Contribution to journalArticle

Volpe, M, Odell, G, Kleinert, HD, Camargot, MJ, Laragh, JH, Lewicki, JA, Maack, T, Vaughan, ED & Atlas, SA 1984, 'Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension', Journal of Hypertension, vol. 2, no. SUPPL. 3, pp. 313-315.
Volpe, M. ; Odell, G. ; Kleinert, H. D. ; Camargot, M. J. ; Laragh, J. H. ; Lewicki, J. A. ; Maack, T. ; Vaughan, E. D. ; Atlas, S. A. / Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension. In: Journal of Hypertension. 1984 ; Vol. 2, No. SUPPL. 3. pp. 313-315.
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AU - Odell, G.

AU - Kleinert, H. D.

AU - Camargot, M. J.

AU - Laragh, J. H.

AU - Lewicki, J. A.

AU - Maack, T.

AU - Vaughan, E. D.

AU - Atlas, S. A.

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