Abstract
Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.
Original language | English |
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Pages (from-to) | 45-49 |
Number of pages | 5 |
Journal | American Journal of Nephrology |
Volume | 6 |
DOIs | |
Publication status | Published - 1986 |
Keywords
- Dopaminergic receptors
- Hypertension
- Metoclopramide
- Renal effects
- Tertatolol
- β-Adrenergic receptors
ASJC Scopus subject areas
- Nephrology