Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients

A. Salvetti; G. Leonetti; G. P. Bernini; L. Rupoli; [No Value] A.R.Lucarini; P. Sangiorgio; M. Mauro; P. Di Stratis; A. Zanchetti

doi:10.1159/000167333

Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients

A. Salvetti, G. Leonetti, G. P. Bernini, L. Rupoli, [No Value] A.R.Lucarini, P. Sangiorgio, M. Mauro, P. Di Stratis, A. Zanchetti

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article

Abstract

Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	American Journal of Nephrology
Volume	6
DOIs	https://doi.org/10.1159/000167333
Publication status	Published - 1986

Keywords

Dopaminergic receptors
Hypertension
Metoclopramide
Renal effects
Tertatolol
β-Adrenergic receptors

ASJC Scopus subject areas

Nephrology

Access to Document

10.1159/000167333

Fingerprint Dive into the research topics of 'Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients'. Together they form a unique fingerprint.

Cite this

Salvetti, A., Leonetti, G., Bernini, G. P., Rupoli, L., A.R.Lucarini, N. V., Sangiorgio, P., Mauro, M., Di Stratis, P., & Zanchetti, A. (1986). Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients. American Journal of Nephrology, 6, 45-49. https://doi.org/10.1159/000167333

@article{6b22b3e97dc84f639d4362a7bf4cd78f,

title = "Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients",

abstract = "Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.",

keywords = "Dopaminergic receptors, Hypertension, Metoclopramide, Renal effects, Tertatolol, β-Adrenergic receptors",

author = "A. Salvetti and G. Leonetti and Bernini, {G. P.} and L. Rupoli and A.R.Lucarini, {[No Value]} and P. Sangiorgio and M. Mauro and {Di Stratis}, P. and A. Zanchetti",

year = "1986",

doi = "10.1159/000167333",

language = "English",

volume = "6",

pages = "45--49",

journal = "American Journal of Nephrology",

issn = "0250-8095",

publisher = "S. Karger AG",

}

TY - JOUR

T1 - Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients

AU - Salvetti, A.

AU - Leonetti, G.

AU - Bernini, G. P.

AU - Rupoli, L.

AU - A.R.Lucarini, [No Value]

AU - Sangiorgio, P.

AU - Mauro, M.

AU - Di Stratis, P.

AU - Zanchetti, A.

PY - 1986

Y1 - 1986

N2 - Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.

AB - Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.

KW - Dopaminergic receptors

KW - Hypertension

KW - Metoclopramide

KW - Renal effects

KW - Tertatolol

KW - β-Adrenergic receptors

UR - http://www.scopus.com/inward/record.url?scp=0023038108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023038108&partnerID=8YFLogxK

U2 - 10.1159/000167333

DO - 10.1159/000167333

M3 - Article

C2 - 2879473

AN - SCOPUS:0023038108

VL - 6

SP - 45

EP - 49

JO - American Journal of Nephrology

JF - American Journal of Nephrology

SN - 0250-8095

ER -