Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients

A. Salvetti; G. Leonetti; G. P. Bernini; L. Rupoli; [No Value] A.R.Lucarini; P. Sangiorgio; M. Mauro; P. Di Stratis; A. Zanchetti

doi:10.1159/000167333

Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients

A. Salvetti, G. Leonetti, G. P. Bernini, L. Rupoli, [No Value] A.R.Lucarini, P. Sangiorgio, M. Mauro, P. Di Stratis, A. Zanchetti

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	American Journal of Nephrology
Volume	6
DOIs	https://doi.org/10.1159/000167333
Publication status	Published - 1986

Keywords

Dopaminergic receptors
Hypertension
Metoclopramide
Renal effects
Tertatolol
β-Adrenergic receptors

ASJC Scopus subject areas

Nephrology

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10.1159/000167333

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Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients. / Salvetti, A.; Leonetti, G.; Bernini, G. P.; Rupoli, L.; A.R.Lucarini, [No Value]; Sangiorgio, P.; Mauro, M.; Di Stratis, P.; Zanchetti, A.

In: American Journal of Nephrology, Vol. 6, 1986, p. 45-49.

Research output: Contribution to journal › Article › peer-review

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abstract = "Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.",

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AU - Salvetti, A.

AU - Leonetti, G.

AU - Bernini, G. P.

AU - Rupoli, L.

AU - A.R.Lucarini, [No Value]

AU - Sangiorgio, P.

AU - Mauro, M.

AU - Di Stratis, P.

AU - Zanchetti, A.

PY - 1986

Y1 - 1986

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AB - Tertatolol, a new nonselective β-adrenoceptor blocker, was administered to 11 hypertensive patients in a short-term study. Systolic and diastolic blood pressure and heart rate were significantly decreased when compared to the placebo period: In spite of that glomerular filtration rate and renal plasma flow were unchanged. The administration of metoclopramide (a dopaminergic receptor antagonist) caused a significant reduction of renal plasma flow and a significant rise of renal vascular resistances during placebo, but no change during tertatolol therapy. A possible interference of tertatolol on dopaminergic receptors is discussed as the mechanism reponsible for the unmodified renal plasma flow despite the significant blood pressure lowering with tertatolol.

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KW - Metoclopramide

KW - Renal effects

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KW - β-Adrenergic receptors

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Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients

Abstract

Keywords

ASJC Scopus subject areas

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