Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients

Gastone Leonetti, Carlo Mazzola, Carlo Pasotti, Laura Angioni, Alvaro Vaccarella, Alberto Capra, G. Bottai, Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review


The antihypertensive efficacy and subjective and physical tol- erability of three different pharmacological treatments (meto- prolol, captopril and the combination of hydrochlorothiazide + amiloride) were compared with placebo in 36 elderly hypertensives (aged 61-79 years), according to a Latin-square double-blind design. The placebo and the active treatments were administered for 2 months. Seated blood pressure was significantly reduced by all the pharmacological treatments compared with placebo, but only metoprolol significantly reduced the heart rate. No haematological or biochemical changes were observed during the study. Physical fitness, evaluated as endurance in a standard cycle ergometer exercise test, was slightly decreased after the treatment with metoprolol and the diuretic combination and slightly improved after treatment with captopril. Subjective tolerability, evaluated by a check-list of symptoms, was better during the active therapies, and in particular during the captopril treatment, than during the placebo treatment. Our results indicate that all three active treatment regimens significantly reduce blood pressure in elderly hypertensives and that captopril appears slightly better tolerated physically and subjectively.

Original languageEnglish
Pages (from-to)S304-S305
JournalJournal of Hypertension, Supplement
Publication statusPublished - 1989


  • Elderly
  • Hypertension
  • Physical fitness
  • Quality of life
  • Treatment

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology


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