Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients

Gastone Leonetti, Carlo Mazzola, Carlo Pasotti, Laura Angioni, Alvaro Vaccarella, Alberto Capra, G. Bottai, Alberto Zanchetti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The antihypertensive efficacy and subjective and physical tol- erability of three different pharmacological treatments (meto- prolol, captopril and the combination of hydrochlorothiazide + amiloride) were compared with placebo in 36 elderly hypertensives (aged 61-79 years), according to a Latin-square double-blind design. The placebo and the active treatments were administered for 2 months. Seated blood pressure was significantly reduced by all the pharmacological treatments compared with placebo, but only metoprolol significantly reduced the heart rate. No haematological or biochemical changes were observed during the study. Physical fitness, evaluated as endurance in a standard cycle ergometer exercise test, was slightly decreased after the treatment with metoprolol and the diuretic combination and slightly improved after treatment with captopril. Subjective tolerability, evaluated by a check-list of symptoms, was better during the active therapies, and in particular during the captopril treatment, than during the placebo treatment. Our results indicate that all three active treatment regimens significantly reduce blood pressure in elderly hypertensives and that captopril appears slightly better tolerated physically and subjectively.

Original languageEnglish
Pages (from-to)S304-S305
JournalJournal of Hypertension, Supplement
Volume7
Publication statusPublished - 1989

Fingerprint

Antihypertensive Agents
Exercise
Metoprolol
Captopril
Placebos
Therapeutics
Pharmacology
Blood Pressure
Physical Fitness
Amiloride
Exercise Test
Diuretics
Heart Rate

Keywords

  • Elderly
  • Hypertension
  • Physical fitness
  • Quality of life
  • Treatment

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

Cite this

Leonetti, G., Mazzola, C., Pasotti, C., Angioni, L., Vaccarella, A., Capra, A., ... Zanchetti, A. (1989). Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients. Journal of Hypertension, Supplement, 7, S304-S305.

Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients. / Leonetti, Gastone; Mazzola, Carlo; Pasotti, Carlo; Angioni, Laura; Vaccarella, Alvaro; Capra, Alberto; Bottai, G.; Zanchetti, Alberto.

In: Journal of Hypertension, Supplement, Vol. 7, 1989, p. S304-S305.

Research output: Contribution to journalArticle

Leonetti, G, Mazzola, C, Pasotti, C, Angioni, L, Vaccarella, A, Capra, A, Bottai, G & Zanchetti, A 1989, 'Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients', Journal of Hypertension, Supplement, vol. 7, pp. S304-S305.
Leonetti, Gastone ; Mazzola, Carlo ; Pasotti, Carlo ; Angioni, Laura ; Vaccarella, Alvaro ; Capra, Alberto ; Bottai, G. ; Zanchetti, Alberto. / Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients. In: Journal of Hypertension, Supplement. 1989 ; Vol. 7. pp. S304-S305.
@article{1432198682224b1999dc7444989fb7b5,
title = "Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients",
abstract = "The antihypertensive efficacy and subjective and physical tol- erability of three different pharmacological treatments (meto- prolol, captopril and the combination of hydrochlorothiazide + amiloride) were compared with placebo in 36 elderly hypertensives (aged 61-79 years), according to a Latin-square double-blind design. The placebo and the active treatments were administered for 2 months. Seated blood pressure was significantly reduced by all the pharmacological treatments compared with placebo, but only metoprolol significantly reduced the heart rate. No haematological or biochemical changes were observed during the study. Physical fitness, evaluated as endurance in a standard cycle ergometer exercise test, was slightly decreased after the treatment with metoprolol and the diuretic combination and slightly improved after treatment with captopril. Subjective tolerability, evaluated by a check-list of symptoms, was better during the active therapies, and in particular during the captopril treatment, than during the placebo treatment. Our results indicate that all three active treatment regimens significantly reduce blood pressure in elderly hypertensives and that captopril appears slightly better tolerated physically and subjectively.",
keywords = "Elderly, Hypertension, Physical fitness, Quality of life, Treatment",
author = "Gastone Leonetti and Carlo Mazzola and Carlo Pasotti and Laura Angioni and Alvaro Vaccarella and Alberto Capra and G. Bottai and Alberto Zanchetti",
year = "1989",
language = "English",
volume = "7",
pages = "S304--S305",
journal = "Journal of Hypertension, Supplement",
issn = "0952-1178",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Antihypertensive efficacy and influence on physical activity of three different treatments in elderly hypertensive patients

AU - Leonetti, Gastone

AU - Mazzola, Carlo

AU - Pasotti, Carlo

AU - Angioni, Laura

AU - Vaccarella, Alvaro

AU - Capra, Alberto

AU - Bottai, G.

AU - Zanchetti, Alberto

PY - 1989

Y1 - 1989

N2 - The antihypertensive efficacy and subjective and physical tol- erability of three different pharmacological treatments (meto- prolol, captopril and the combination of hydrochlorothiazide + amiloride) were compared with placebo in 36 elderly hypertensives (aged 61-79 years), according to a Latin-square double-blind design. The placebo and the active treatments were administered for 2 months. Seated blood pressure was significantly reduced by all the pharmacological treatments compared with placebo, but only metoprolol significantly reduced the heart rate. No haematological or biochemical changes were observed during the study. Physical fitness, evaluated as endurance in a standard cycle ergometer exercise test, was slightly decreased after the treatment with metoprolol and the diuretic combination and slightly improved after treatment with captopril. Subjective tolerability, evaluated by a check-list of symptoms, was better during the active therapies, and in particular during the captopril treatment, than during the placebo treatment. Our results indicate that all three active treatment regimens significantly reduce blood pressure in elderly hypertensives and that captopril appears slightly better tolerated physically and subjectively.

AB - The antihypertensive efficacy and subjective and physical tol- erability of three different pharmacological treatments (meto- prolol, captopril and the combination of hydrochlorothiazide + amiloride) were compared with placebo in 36 elderly hypertensives (aged 61-79 years), according to a Latin-square double-blind design. The placebo and the active treatments were administered for 2 months. Seated blood pressure was significantly reduced by all the pharmacological treatments compared with placebo, but only metoprolol significantly reduced the heart rate. No haematological or biochemical changes were observed during the study. Physical fitness, evaluated as endurance in a standard cycle ergometer exercise test, was slightly decreased after the treatment with metoprolol and the diuretic combination and slightly improved after treatment with captopril. Subjective tolerability, evaluated by a check-list of symptoms, was better during the active therapies, and in particular during the captopril treatment, than during the placebo treatment. Our results indicate that all three active treatment regimens significantly reduce blood pressure in elderly hypertensives and that captopril appears slightly better tolerated physically and subjectively.

KW - Elderly

KW - Hypertension

KW - Physical fitness

KW - Quality of life

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=0024953347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024953347&partnerID=8YFLogxK

M3 - Article

C2 - 2698943

AN - SCOPUS:0024953347

VL - 7

SP - S304-S305

JO - Journal of Hypertension, Supplement

JF - Journal of Hypertension, Supplement

SN - 0952-1178

ER -