Abstract
PURPOSE OF REVIEW: Stroke represents the most devastating cardiovascular disease in the Western world, accounting for approximately 700 000 cases each year, including 500 000 first attacks and 200 000 recurrent episodes. High blood pressure is the most relevant modifiable risk factor for developing stroke. RECENT FINDINGS: In hypertensive patients, especially those with additional cardiovascular risk factors or clinical settings such as diabetes, target organ damage or associated clinical conditions, even small decreases in blood pressure levels are associated with large reductions in the incidence of cerebrovascular events. The benefits of blood pressure reductions, however, are not strictly proportional to stroke incidence, and it has been recently postulated that the different classes of antihypertensive drugs may have specific properties for organ protection and cerebrovascular accident prevention. SUMMARY: In particular, the hypothesis of a higher cerebrovascular protection provided by newer antihypertensive agents with respect to the conventional antihypertensive therapy is an attractive perspective that deserves further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 498-504 |
| Number of pages | 7 |
| Journal | Current Opinion in Nephrology and Hypertension |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 2006 |
Fingerprint
Keywords
- Angiotensin II receptor blockers
- Antihypertensive therapy
- Calcium-channel blockers
- Cerebrovascular disease
- Hypertension
- Stroke
ASJC Scopus subject areas
- Nephrology
- Internal Medicine
Cite this
Antihypertensive therapy and cerebrovascular protection. / Volpe, Massimo; Tocci, Giuliano.
In: Current Opinion in Nephrology and Hypertension, Vol. 15, No. 5, 09.2006, p. 498-504.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antihypertensive therapy and cerebrovascular protection
AU - Volpe, Massimo
AU - Tocci, Giuliano
PY - 2006/9
Y1 - 2006/9
N2 - PURPOSE OF REVIEW: Stroke represents the most devastating cardiovascular disease in the Western world, accounting for approximately 700 000 cases each year, including 500 000 first attacks and 200 000 recurrent episodes. High blood pressure is the most relevant modifiable risk factor for developing stroke. RECENT FINDINGS: In hypertensive patients, especially those with additional cardiovascular risk factors or clinical settings such as diabetes, target organ damage or associated clinical conditions, even small decreases in blood pressure levels are associated with large reductions in the incidence of cerebrovascular events. The benefits of blood pressure reductions, however, are not strictly proportional to stroke incidence, and it has been recently postulated that the different classes of antihypertensive drugs may have specific properties for organ protection and cerebrovascular accident prevention. SUMMARY: In particular, the hypothesis of a higher cerebrovascular protection provided by newer antihypertensive agents with respect to the conventional antihypertensive therapy is an attractive perspective that deserves further investigation.
AB - PURPOSE OF REVIEW: Stroke represents the most devastating cardiovascular disease in the Western world, accounting for approximately 700 000 cases each year, including 500 000 first attacks and 200 000 recurrent episodes. High blood pressure is the most relevant modifiable risk factor for developing stroke. RECENT FINDINGS: In hypertensive patients, especially those with additional cardiovascular risk factors or clinical settings such as diabetes, target organ damage or associated clinical conditions, even small decreases in blood pressure levels are associated with large reductions in the incidence of cerebrovascular events. The benefits of blood pressure reductions, however, are not strictly proportional to stroke incidence, and it has been recently postulated that the different classes of antihypertensive drugs may have specific properties for organ protection and cerebrovascular accident prevention. SUMMARY: In particular, the hypothesis of a higher cerebrovascular protection provided by newer antihypertensive agents with respect to the conventional antihypertensive therapy is an attractive perspective that deserves further investigation.
KW - Angiotensin II receptor blockers
KW - Antihypertensive therapy
KW - Calcium-channel blockers
KW - Cerebrovascular disease
KW - Hypertension
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=33747389709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747389709&partnerID=8YFLogxK
U2 - 10.1097/01.mnh.0000242175.59823.f2
DO - 10.1097/01.mnh.0000242175.59823.f2
M3 - Article
C2 - 16914962
AN - SCOPUS:33747389709
VL - 15
SP - 498
EP - 504
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
SN - 1062-4821
IS - 5
ER -