Antihypertensive therapy in patients above age 60 with systolic hypertension

A. Amery, W. Birkenhäger, M. Bogaert, P. Brixko, C. Bulpitt, D. Clement, P. De Leeuw, J. F. De Plaen, M. Deruyttere, A. De Schaepdryver, R. Fagard, F. Forette, J. Forte, R. Hamdy, J. Hellemans, J. F. Henry, A. Koistinen, U. Laaser, M. Laher, G. LeonettiP. Lewis, P. Lund-Johansen, J. Macfarlane, K. Meurer, P. Miguel, J. Morris, A. Mutsers, A. Nissinen, E. O'brien, O. J. Ohm, K. O'malley, W. Pelemans, N. Perera, J. Tuomilehto, L. J. Verschueren, P. Willemse, B. Williams, A. Zanchetti

Research output: Contribution to journalArticle

Abstract

1. Although systolic blood pressure elevation is responsible for increased incidence of cardiovascular accidents in old people, the preventive benefit of lowering systolic hypertension in elderly has not been confirmed. 2. A double blind study comparing the effects of a placebo and of an active regimen (hydrochloro-thiazide-triamterene with or without methyldopa) in people over 60 years with isolated systolic hypertension has been undertaken by the European Working Party on High blood pressure in the Elderly (EWPHE). 3. The actively treated group shows a lowered sitting blood pressure (-15/6 mm Hg), a mild increase of serum creatine, serum uric acid and blood glucose and a mild decrease of serum potassium after two years of treatment when compared to the spontaneous changes observed in the placebo treated group. 4. The study is continuing to evaluate if the blood pressure reduction prevents or reduces t he incidence of cardiovascular accidents, although some biochemical changes were provoked by the treatment.

Original languageEnglish
Pages (from-to)1151-1176
Number of pages26
JournalClinical and Experimental Hypertension
VolumeA4
Issue number7
DOIs
Publication statusPublished - 1982

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Antihypertensive Agents
Blood Pressure
Hypertension
Accidents
Serum
Triamterene
Thiazides
Methyldopa
Placebo Effect
Creatine
Incidence
Therapeutics
Uric Acid
Double-Blind Method
Blood Glucose
Potassium
Placebos

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Amery, A., Birkenhäger, W., Bogaert, M., Brixko, P., Bulpitt, C., Clement, D., ... Zanchetti, A. (1982). Antihypertensive therapy in patients above age 60 with systolic hypertension. Clinical and Experimental Hypertension, A4(7), 1151-1176. https://doi.org/10.3109/10641968209060781

Antihypertensive therapy in patients above age 60 with systolic hypertension. / Amery, A.; Birkenhäger, W.; Bogaert, M.; Brixko, P.; Bulpitt, C.; Clement, D.; Leeuw, P. De; De Plaen, J. F.; Deruyttere, M.; De Schaepdryver, A.; Fagard, R.; Forette, F.; Forte, J.; Hamdy, R.; Hellemans, J.; Henry, J. F.; Koistinen, A.; Laaser, U.; Laher, M.; Leonetti, G.; Lewis, P.; Lund-Johansen, P.; Macfarlane, J.; Meurer, K.; Miguel, P.; Morris, J.; Mutsers, A.; Nissinen, A.; O'brien, E.; Ohm, O. J.; O'malley, K.; Pelemans, W.; Perera, N.; Tuomilehto, J.; Verschueren, L. J.; Willemse, P.; Williams, B.; Zanchetti, A.

In: Clinical and Experimental Hypertension, Vol. A4, No. 7, 1982, p. 1151-1176.

Research output: Contribution to journalArticle

Amery, A, Birkenhäger, W, Bogaert, M, Brixko, P, Bulpitt, C, Clement, D, Leeuw, PD, De Plaen, JF, Deruyttere, M, De Schaepdryver, A, Fagard, R, Forette, F, Forte, J, Hamdy, R, Hellemans, J, Henry, JF, Koistinen, A, Laaser, U, Laher, M, Leonetti, G, Lewis, P, Lund-Johansen, P, Macfarlane, J, Meurer, K, Miguel, P, Morris, J, Mutsers, A, Nissinen, A, O'brien, E, Ohm, OJ, O'malley, K, Pelemans, W, Perera, N, Tuomilehto, J, Verschueren, LJ, Willemse, P, Williams, B & Zanchetti, A 1982, 'Antihypertensive therapy in patients above age 60 with systolic hypertension', Clinical and Experimental Hypertension, vol. A4, no. 7, pp. 1151-1176. https://doi.org/10.3109/10641968209060781
Amery, A. ; Birkenhäger, W. ; Bogaert, M. ; Brixko, P. ; Bulpitt, C. ; Clement, D. ; Leeuw, P. De ; De Plaen, J. F. ; Deruyttere, M. ; De Schaepdryver, A. ; Fagard, R. ; Forette, F. ; Forte, J. ; Hamdy, R. ; Hellemans, J. ; Henry, J. F. ; Koistinen, A. ; Laaser, U. ; Laher, M. ; Leonetti, G. ; Lewis, P. ; Lund-Johansen, P. ; Macfarlane, J. ; Meurer, K. ; Miguel, P. ; Morris, J. ; Mutsers, A. ; Nissinen, A. ; O'brien, E. ; Ohm, O. J. ; O'malley, K. ; Pelemans, W. ; Perera, N. ; Tuomilehto, J. ; Verschueren, L. J. ; Willemse, P. ; Williams, B. ; Zanchetti, A. / Antihypertensive therapy in patients above age 60 with systolic hypertension. In: Clinical and Experimental Hypertension. 1982 ; Vol. A4, No. 7. pp. 1151-1176.
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AU - Clement, D.

AU - Leeuw, P. De

AU - De Plaen, J. F.

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AU - De Schaepdryver, A.

AU - Fagard, R.

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AU - Forte, J.

AU - Hamdy, R.

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AU - Pelemans, W.

AU - Perera, N.

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AU - Zanchetti, A.

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