TY - JOUR
T1 - Antihypertensive treatments in patients affected by aortic valve stenosis
AU - Poggio, Paolo
AU - Folesani, Gianluca
AU - Raffa, Giuseppe M.
AU - Songia, Paola
AU - Valenti, Vincenzo
AU - Myasoedova, Veronika
AU - Parolari, Alessandro
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Systemic hypertension and aortic valve stenosis (AVS) are both age-related diseases. Severe aortic stenosis affects ≈2% to 5% of adults age > 65 years. Systemic hypertension is a frequent comorbidity in patients with AVS and is coexistent for a longer period of time before AVS is treated. Essential systemic hypertension, per se, plays an important role in the creation of lesions on the aortic side of the valve, the region of higher exposure to tension stress. The subsequent endothelial defect represents the principal site of inflammatory process and oxidative stress, leading to aortic sclerosis and calcification. In this review, we want to describe the pharmacological features of the common antihypertensive drugs, analysing the recent literature, in order to achieve useful and updated information about the best treatment of systemic hypertension in patients with concomitant severe aortic stenosis.
AB - Systemic hypertension and aortic valve stenosis (AVS) are both age-related diseases. Severe aortic stenosis affects ≈2% to 5% of adults age > 65 years. Systemic hypertension is a frequent comorbidity in patients with AVS and is coexistent for a longer period of time before AVS is treated. Essential systemic hypertension, per se, plays an important role in the creation of lesions on the aortic side of the valve, the region of higher exposure to tension stress. The subsequent endothelial defect represents the principal site of inflammatory process and oxidative stress, leading to aortic sclerosis and calcification. In this review, we want to describe the pharmacological features of the common antihypertensive drugs, analysing the recent literature, in order to achieve useful and updated information about the best treatment of systemic hypertension in patients with concomitant severe aortic stenosis.
KW - ACEi/ARB
KW - Alpa- beta-blockers
KW - Antihypertensive drugs
KW - Aortic valve stenosis
KW - Calcium channel blockers
KW - Diuretics
KW - Hypertension
KW - Vasodilators
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U2 - 10.2174/1381612823666161123144534
DO - 10.2174/1381612823666161123144534
M3 - Review article
AN - SCOPUS:85020846897
VL - 23
SP - 1188
EP - 1194
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 8
ER -