Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-, 1,5-benzodiazepine-4-one) in the rat and mouse

S. Caccia, M. Ballabio, M. G. Zanini, S. Garattini, R. Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

The antileptazol effect of CP 1414 S (7-nitro-2-amino-3-phenyl-3H-!,5-benzodiazepine-4-one) a newly developed 1,5 benzodiazepine,lasts longer in mice than in rats. After intraperitoneal injection (10 mg/kg) brain levels of the drug were higher and persisted for longer in the mouse than in the rat. Although it cannot be excluded that possible metabolites of CP 1414 S may contribute to the anticonvulsant effect of CP 1414 S, in both species the protective effect correlates well with the brain concentrations of the drug.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 1982

Keywords

  • antileptazol activity
  • CP 1414 S. Benzodiazepines
  • kinetic

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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