Abstract
The antileptazol effect of CP 1414 S (7-nitro-2-amino-3-phenyl-3H-!,5-benzodiazepine-4-one) a newly developed 1,5 benzodiazepine,lasts longer in mice than in rats. After intraperitoneal injection (10 mg/kg) brain levels of the drug were higher and persisted for longer in the mouse than in the rat. Although it cannot be excluded that possible metabolites of CP 1414 S may contribute to the anticonvulsant effect of CP 1414 S, in both species the protective effect correlates well with the brain concentrations of the drug.
Original language | English |
---|---|
Pages (from-to) | 93-97 |
Number of pages | 5 |
Journal | European Journal of Drug Metabolism and Pharmacokinetics |
Volume | 7 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 1982 |
Keywords
- antileptazol activity
- CP 1414 S. Benzodiazepines
- kinetic
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)