Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-, 1,5-benzodiazepine-4-one) in the rat and mouse

S. Caccia; M. Ballabio; M. G. Zanini; S. Garattini; R. Samanin

doi:10.1007/BF03188724

Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-, 1,5-benzodiazepine-4-one) in the rat and mouse

S. Caccia, M. Ballabio, M. G. Zanini, S. Garattini, R. Samanin

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The antileptazol effect of CP 1414 S (7-nitro-2-amino-3-phenyl-3H-!,5-benzodiazepine-4-one) a newly developed 1,5 benzodiazepine,lasts longer in mice than in rats. After intraperitoneal injection (10 mg/kg) brain levels of the drug were higher and persisted for longer in the mouse than in the rat. Although it cannot be excluded that possible metabolites of CP 1414 S may contribute to the anticonvulsant effect of CP 1414 S, in both species the protective effect correlates well with the brain concentrations of the drug.

Original language	English
Pages (from-to)	93-97
Number of pages	5
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/BF03188724
Publication status	Published - Apr 1982

Keywords

antileptazol activity
CP 1414 S. Benzodiazepines
kinetic

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/BF03188724

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abstract = "The antileptazol effect of CP 1414 S (7-nitro-2-amino-3-phenyl-3H-!,5-benzodiazepine-4-one) a newly developed 1,5 benzodiazepine,lasts longer in mice than in rats. After intraperitoneal injection (10 mg/kg) brain levels of the drug were higher and persisted for longer in the mouse than in the rat. Although it cannot be excluded that possible metabolites of CP 1414 S may contribute to the anticonvulsant effect of CP 1414 S, in both species the protective effect correlates well with the brain concentrations of the drug.",

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AU - Ballabio, M.

AU - Zanini, M. G.

AU - Garattini, S.

AU - Samanin, R.

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Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-, 1,5-benzodiazepine-4-one) in the rat and mouse

Abstract

Keywords

ASJC Scopus subject areas

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