The kinetic profiles and antileptazol activity of clobazam and its main metabolite were compared to assess the metabolite's contribution to the anticonvulsant activity of clobazam in the guinea-pig. The metabolite was less effective than the parent compound in terms of doses and active brain levels. However, the metabolite formed after clobazam administration accounted for the persistence of antileptazol activity in this animal species.
|Number of pages||8|
|Journal||Archives Internationales de Pharmacodynamie et de Therapie|
|Publication status||Published - 1981|
ASJC Scopus subject areas