Antileptazol activity and kinetics of clobazam and N-desmethyl-clobazam in the guinea-pig

M. Ballabio, S. Caccia, S. Garattini, G. Guiso, M. G. Zanini

Research output: Contribution to journalArticle

Abstract

The kinetic profiles and antileptazol activity of clobazam and its main metabolite were compared to assess the metabolite's contribution to the anticonvulsant activity of clobazam in the guinea-pig. The metabolite was less effective than the parent compound in terms of doses and active brain levels. However, the metabolite formed after clobazam administration accounted for the persistence of antileptazol activity in this animal species.

Original languageEnglish
Pages (from-to)192-199
Number of pages8
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume253
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Pharmacology

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