Abstract
Although several studies have attempted to determine the usefulness of antibiotic prophylaxis in patients undergoing CSF shunt surgery, it is impossible to define exactly its effect on the incidence of infections. Many trials are unsuitable for statistical analysis and the true incidence of different bacterial strains varies from unit to unit. We evaluated 52 cases of CSF shunt infections that occurred in our neurosurgical department in the last five years. On the basis of the strains isolated, we propose an antimicrobial prophylaxis for CSF shunt surgery based on administration of vancomycin 20 mg and amikacin 10 mg in a single dose, instilled directly in the IVT shunt at the time of surgical procedure. We evaluated the rate of infections, the kinetics of the two antibiotics and the incidence of ototoxicity or other neurologic sequelae in nine CSF shunt-surgery patients. We found that the use of vancomycin and amikacin through intraventricular injection is safe and provides 1-20 times the minimum inhibitory concentration for staphylococci.
| Original language | Italian |
|---|---|
| Pages (from-to) | 67-70 |
| Number of pages | 4 |
| Journal | Microbiologia Medica |
| Volume | 12 |
| Issue number | 2 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Microbiology (medical)
Cite this
Infezioni di derivazioni ventricolari e profilassi antibiotica. / Marone, P.; Carretto, E.; Tartara, F.; Segu, C.; Rondanelli, M.
In: Microbiologia Medica, Vol. 12, No. 2, 1997, p. 67-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infezioni di derivazioni ventricolari e profilassi antibiotica
AU - Marone, P.
AU - Carretto, E.
AU - Tartara, F.
AU - Segu, C.
AU - Rondanelli, M.
PY - 1997
Y1 - 1997
N2 - Although several studies have attempted to determine the usefulness of antibiotic prophylaxis in patients undergoing CSF shunt surgery, it is impossible to define exactly its effect on the incidence of infections. Many trials are unsuitable for statistical analysis and the true incidence of different bacterial strains varies from unit to unit. We evaluated 52 cases of CSF shunt infections that occurred in our neurosurgical department in the last five years. On the basis of the strains isolated, we propose an antimicrobial prophylaxis for CSF shunt surgery based on administration of vancomycin 20 mg and amikacin 10 mg in a single dose, instilled directly in the IVT shunt at the time of surgical procedure. We evaluated the rate of infections, the kinetics of the two antibiotics and the incidence of ototoxicity or other neurologic sequelae in nine CSF shunt-surgery patients. We found that the use of vancomycin and amikacin through intraventricular injection is safe and provides 1-20 times the minimum inhibitory concentration for staphylococci.
AB - Although several studies have attempted to determine the usefulness of antibiotic prophylaxis in patients undergoing CSF shunt surgery, it is impossible to define exactly its effect on the incidence of infections. Many trials are unsuitable for statistical analysis and the true incidence of different bacterial strains varies from unit to unit. We evaluated 52 cases of CSF shunt infections that occurred in our neurosurgical department in the last five years. On the basis of the strains isolated, we propose an antimicrobial prophylaxis for CSF shunt surgery based on administration of vancomycin 20 mg and amikacin 10 mg in a single dose, instilled directly in the IVT shunt at the time of surgical procedure. We evaluated the rate of infections, the kinetics of the two antibiotics and the incidence of ototoxicity or other neurologic sequelae in nine CSF shunt-surgery patients. We found that the use of vancomycin and amikacin through intraventricular injection is safe and provides 1-20 times the minimum inhibitory concentration for staphylococci.
KW - Amikacin
KW - Antimicrobial prophylaxis
KW - CSF shunt infection
KW - Vancomycin
UR - http://www.scopus.com/inward/record.url?scp=0031397915&partnerID=8YFLogxK
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M3 - Articolo
AN - SCOPUS:0031397915
VL - 12
SP - 67
EP - 70
JO - Microbiologia Medica
JF - Microbiologia Medica
SN - 1120-0146
IS - 2
ER -