TY - JOUR
T1 - Antimitochondrial effect of saturated medium chain length (C8-C13) dicarboxylic acids
AU - Passi, Siro
AU - Picardo, Mauro
AU - Nazzaro-Porro, Marcella
AU - Breathnach, Aodan
AU - Confaloni, Anna Maria
AU - Serlupi-Crescenzi, Giovanni
PY - 1984/1/1
Y1 - 1984/1/1
N2 - In isolated rat liver mitochondria, respiration was competitively inhibited by medium chain length (C8 to C13) dicarboxylic acids to different extents: the higher the number of carbon atoms up to C12, the greater the inhibition. In particular, experiments on submitochondrial particles showed that the competitive inhibition concerned the following enzymes: NADH dehydrogenase, succinic dehydrogenase and reduced ubiquinone: cytochrome c oxido-reductase. These results tend to confirm the suggestion that the melanocytotoxic effect of dicarboxylic acids, which are also competitive inhibitors of tyrosinase, may be primarily due to an antimitochondrial effect rather than being tyrosinase-dependent.
AB - In isolated rat liver mitochondria, respiration was competitively inhibited by medium chain length (C8 to C13) dicarboxylic acids to different extents: the higher the number of carbon atoms up to C12, the greater the inhibition. In particular, experiments on submitochondrial particles showed that the competitive inhibition concerned the following enzymes: NADH dehydrogenase, succinic dehydrogenase and reduced ubiquinone: cytochrome c oxido-reductase. These results tend to confirm the suggestion that the melanocytotoxic effect of dicarboxylic acids, which are also competitive inhibitors of tyrosinase, may be primarily due to an antimitochondrial effect rather than being tyrosinase-dependent.
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U2 - 10.1016/0006-2952(84)90376-9
DO - 10.1016/0006-2952(84)90376-9
M3 - Article
C2 - 6704136
AN - SCOPUS:0021319464
VL - 33
SP - 103
EP - 108
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 1
ER -