Antimycobacterial chemotherapy in inflammatory bowel disease

A. Picciotto, G. P. Gesu, G. C. Schito, R. Testa, G. Varagona, G. Celle

Research output: Contribution to journalArticle

Abstract

We report on a case, ulcerative colitis and another of Crohn's disease. During a relapse which was unresponsive to conventional therapy, acid-fast bacilli were found in colonie biopsies. Conventional therapy was substituted with antimycobacterial chemotherapy (rifampicin, isoniazid and ethambutol) which was responsible for a marked improvement. However, a relapse occurred during chemotherapy and no acid-fast bacilli were found. The patients became responsive to sulphasalazine and corticosteroid therapy once again. It appears that Mycobacteria play a collateral role in inflammatory bowel disease and that once they have been eliminated the original disease re-emerges. inflammatory bowel disease / antimycobacterial chemotherapy / relapse.

Original languageEnglish
Pages (from-to)141-143
Number of pages3
JournalBiomedicine and Pharmacotherapy
Volume43
Issue number2
DOIs
Publication statusPublished - 1989

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Inflammatory Bowel Diseases
Recurrence
Drug Therapy
Bacillus
Sulfasalazine
Ethambutol
Acids
Isoniazid
Rifampin
Mycobacterium
Ulcerative Colitis
Crohn Disease
Adrenal Cortex Hormones
Therapeutics
Biopsy

ASJC Scopus subject areas

  • Pharmacology

Cite this

Antimycobacterial chemotherapy in inflammatory bowel disease. / Picciotto, A.; Gesu, G. P.; Schito, G. C.; Testa, R.; Varagona, G.; Celle, G.

In: Biomedicine and Pharmacotherapy, Vol. 43, No. 2, 1989, p. 141-143.

Research output: Contribution to journalArticle

Picciotto, A, Gesu, GP, Schito, GC, Testa, R, Varagona, G & Celle, G 1989, 'Antimycobacterial chemotherapy in inflammatory bowel disease', Biomedicine and Pharmacotherapy, vol. 43, no. 2, pp. 141-143. https://doi.org/10.1016/0753-3322(89)90143-1
Picciotto, A. ; Gesu, G. P. ; Schito, G. C. ; Testa, R. ; Varagona, G. ; Celle, G. / Antimycobacterial chemotherapy in inflammatory bowel disease. In: Biomedicine and Pharmacotherapy. 1989 ; Vol. 43, No. 2. pp. 141-143.
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