Antimycotic activity of Achillea ageratum L. essential oil

E. Vavala, R. Ragno, S. Sivric, G. Sartorelli, A. Filippi, A. T. Palamara, L. Angiolella

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we evaluated the antimycotic activity of Achillea ageratum essential oil against Candida albicans. The principal components of the essential oil were yomogi alcohol, 1,8-cineole, artemisia treine and artemisia alcohol. Most strains of C. albicans tested had an MIC 2.25 μg/ml and an MFC between 2.25 and 4.5 μg/ml; the MIC and MFC were low when compared to fluconazole. We also demonstrated that the essential oil was able to affect the major virulence factors of C. albicans; the inhibition of germ tube formation at the sub-inhibitory concentration of 0.29 μg/ml and the inhibition of biofilm formation by over 60% at a concentration of 9 μg/ml. In conclusion, Achillea ageratum essential oil showed a good activity in vitro against C. albicans and may be potentially used as anticandida agent. To support this, further studies are in preparaton to confirm these results.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalInternational Journal of Essential Oil Therapeutics
Volume3
Issue number2-3
Publication statusPublished - 2009

Keywords

  • Achillea ageratum
  • Antimycotic activity
  • Biofilm
  • Candida albicans
  • Essential oil

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Pharmacology (medical)
  • Pharmaceutical Science

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