Antineoplastic activity and pharmacokinetics of adriamycin and daunomycin in tumor bearing mice

A. Martini, M. G. Donelli, A. Mantovani, M. A. Pacciarini, E. F. Fogar-Ottaviano, L. Morasca, S. Garattini, F. S. Spreafico

Research output: Contribution to journalArticle

Abstract

In C57B1/6 mice bearing the intramuscular Lewis lung carcinoma, single intravenous doses of Adriamycin showed an higher antineoplastic effectiveness on the primary tumor and its lung metastasis than equal doses of its analog Daunomycin. The in vitro cell-binding of Daunomycin to these tumor cells was higher than that of Adriamycin, but no differences in cytotoxicity were found between the two agents. Pharmacokinetic studies revealed that Adriamycin (and/or its metabolites) accumulated in the neoplastic tissue more promptly, in significantly greater quantities and for longer period than Daunomycin.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalOncology
Volume34
Issue number4
Publication statusPublished - 1977

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Martini, A., Donelli, M. G., Mantovani, A., Pacciarini, M. A., Fogar-Ottaviano, E. F., Morasca, L., Garattini, S., & Spreafico, F. S. (1977). Antineoplastic activity and pharmacokinetics of adriamycin and daunomycin in tumor bearing mice. Oncology, 34(4), 173-178.