Antineutrophil cytoplasmic antibodies in inflammatory bowel disease: Clinical role and review of the literature

Giovanni Lombardi, Vito Annese, Ada Piepoli, Paola Bovio, Anna Latiano, Grazia Napolitano, Francesco Perri, Pasquale Conoscitore, Angelo Andriulli

Research output: Contribution to journalArticlepeer-review


PURPOSE: Perinuclear antineutrophil cytoplasmic antibodies have been found consistently in patients with ulcerative colitis; however, their pathogenetic and clinical role is still uncertain. In this study we tested the prevalence of perinuclear antineutrophil cytoplasmic antibodies in a large population of patients with ulcerative colitis and Crohn's disease, with particular attention to the possible correlation with clinical features. METHODS: Perinuclear antineutrophil cytoplasmic antibody reactivity was investigated with indirect immunofluorescence in 279 patients with ulcerative colitis, 110 patients with Crohn's disease, and 252 unrelated healthy subjects. RESULTS: Perinuclear antineutrophil cytoplasmic antibodies were found in 84 of 279 patients with ulcerative colitis (30 percent), 10 of 110 patients with Crohn's disease (9 percent), and 2 of 252 healthy subjects (

Original languageEnglish
Pages (from-to)999-1007
Number of pages9
JournalDiseases of the Colon and Rectum
Issue number7
Publication statusPublished - Jul 2000


  • Antineutrophil cytoplasmic antibodies
  • Crohn's disease
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology


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