Antineutrophil cytoplasmic antibodies in inflammatory bowel disease: Clinical role and review of the literature

Giovanni Lombardi, Vito Annese, Ada Piepoli, Paola Bovio, Anna Latiano, Grazia Napolitano, Francesco Perri, Pasquale Conoscitore, Angelo Andriulli

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

PURPOSE: Perinuclear antineutrophil cytoplasmic antibodies have been found consistently in patients with ulcerative colitis; however, their pathogenetic and clinical role is still uncertain. In this study we tested the prevalence of perinuclear antineutrophil cytoplasmic antibodies in a large population of patients with ulcerative colitis and Crohn's disease, with particular attention to the possible correlation with clinical features. METHODS: Perinuclear antineutrophil cytoplasmic antibody reactivity was investigated with indirect immunofluorescence in 279 patients with ulcerative colitis, 110 patients with Crohn's disease, and 252 unrelated healthy subjects. RESULTS: Perinuclear antineutrophil cytoplasmic antibodies were found in 84 of 279 patients with ulcerative colitis (30 percent), 10 of 110 patients with Crohn's disease (9 percent), and 2 of 252 healthy subjects (

Original languageEnglish
Pages (from-to)999-1007
Number of pages9
JournalDiseases of the Colon and Rectum
Volume43
Issue number7
Publication statusPublished - Jul 2000

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Antineutrophil Cytoplasmic Antibodies
Inflammatory Bowel Diseases
Ulcerative Colitis
Crohn Disease
Healthy Volunteers
Indirect Fluorescent Antibody Technique
Cross-Sectional Studies
Population

Keywords

  • Antineutrophil cytoplasmic antibodies
  • Crohn's disease
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Antineutrophil cytoplasmic antibodies in inflammatory bowel disease : Clinical role and review of the literature. / Lombardi, Giovanni; Annese, Vito; Piepoli, Ada; Bovio, Paola; Latiano, Anna; Napolitano, Grazia; Perri, Francesco; Conoscitore, Pasquale; Andriulli, Angelo.

In: Diseases of the Colon and Rectum, Vol. 43, No. 7, 07.2000, p. 999-1007.

Research output: Contribution to journalArticle

Lombardi, Giovanni ; Annese, Vito ; Piepoli, Ada ; Bovio, Paola ; Latiano, Anna ; Napolitano, Grazia ; Perri, Francesco ; Conoscitore, Pasquale ; Andriulli, Angelo. / Antineutrophil cytoplasmic antibodies in inflammatory bowel disease : Clinical role and review of the literature. In: Diseases of the Colon and Rectum. 2000 ; Vol. 43, No. 7. pp. 999-1007.
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AU - Perri, Francesco

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