Antinflammatory, antimicrobial, comedolytic effects of a topical plant complex treatment in acne vulgaris: A clinical trial

Barbara Beltrami, C. Vassallo, E. Berardesca, G. Borroni

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Acne is a disease of the pilosebaceous unit and it may be characterized by non inflammatory lesions, such as comedones and cysts and/or by inflammatory lesions such as erythematous papules, pustules, nodules. The lesions may or may not resolve with scars. Three major factors are involved in the pathogenesis of acne: increased sebum production, an abnormality of the microbial flora, cornification of the infundibula duct. These three components represent the target of different plant extracts, which may play an important role in inducing comedolytic, antimicrobial effects and also in improving pitted scars. This study was aimed at evaluating the efficacy of a topical plant complex treatment in acne vulgaris in 30 volunteers. These volunteers were divided in two groups: 15 received only the topical treatment and 15 received topical treatment plus oral placebo capsules. The instrumental investigation evaluated the following parameters during 90 days: skin hydration, transepidermal water loss, erythema, skin brightness, sebum on skin surface, scars. The statistical analysis of data at the end of this clinical trial underlined that the topical plant complex product improves the clinical appearance of acne.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalJournal of Applied Cosmetology
Issue number1
Publication statusPublished - Jan 2001



  • Acne
  • Biophysical cutaneous parameters
  • Plant complex

ASJC Scopus subject areas

  • Dermatology

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