Antinociceptive effect of centrally administered endothelin-1 and endothelin-3 in the mouse

R. Nikolov; I. Semkova; J. Maslarova; S. Moyanova

Antinociceptive effect of centrally administered endothelin-1 and endothelin-3 in the mouse

R. Nikolov, I. Semkova, J. Maslarova, S. Moyanova

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Abstract

The antinociceptive effects of centrally administered (i.c.v.) endothelin- 1 (ET-1) and endothelin-3 (ET-3) were studied in mice by the use of 3 experimental procedures: hot plate, tail flick and acetic acid writhing tests. ET-1 (0.625-5 pmol/mouse) and ET-3 (2.5-25 pmol/mouse) produced statistically significant increase of the hot plate and tail flick latencies with duration of about 120 min. ET-3 showed weaker antinociceptive effect. ET-1 inhibited acetic acid-induced writhings with ED₅₀ = 1.9 (1.1-2.7) pmol/mouse. With ET-3 a maximum effect of 45.2% suppression of the writhing response was achieved at 5 pmol/mouse. The antinociception due to ET-1 and ET-3 was not antagonized by naloxone and is thus independent of endogenous opioid release.

Original language	English
Pages (from-to)	447-453
Number of pages	7
Journal	Methods and Findings in Experimental and Clinical Pharmacology
Volume	15
Issue number	7
Publication status	Published - 1993

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Antinociceptive effect of centrally administered endothelin-1 and endothelin-3 in the mouse",

abstract = "The antinociceptive effects of centrally administered (i.c.v.) endothelin- 1 (ET-1) and endothelin-3 (ET-3) were studied in mice by the use of 3 experimental procedures: hot plate, tail flick and acetic acid writhing tests. ET-1 (0.625-5 pmol/mouse) and ET-3 (2.5-25 pmol/mouse) produced statistically significant increase of the hot plate and tail flick latencies with duration of about 120 min. ET-3 showed weaker antinociceptive effect. ET-1 inhibited acetic acid-induced writhings with ED50 = 1.9 (1.1-2.7) pmol/mouse. With ET-3 a maximum effect of 45.2% suppression of the writhing response was achieved at 5 pmol/mouse. The antinociception due to ET-1 and ET-3 was not antagonized by naloxone and is thus independent of endogenous opioid release.",

author = "R. Nikolov and I. Semkova and J. Maslarova and S. Moyanova",

year = "1993",

language = "English",

volume = "15",

pages = "447--453",

journal = "Methods and Findings in Experimental and Clinical Pharmacology",

issn = "0379-0355",

publisher = "Prous Science",

number = "7",

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TY - JOUR

T1 - Antinociceptive effect of centrally administered endothelin-1 and endothelin-3 in the mouse

AU - Nikolov, R.

AU - Semkova, I.

AU - Maslarova, J.

AU - Moyanova, S.

PY - 1993

Y1 - 1993

N2 - The antinociceptive effects of centrally administered (i.c.v.) endothelin- 1 (ET-1) and endothelin-3 (ET-3) were studied in mice by the use of 3 experimental procedures: hot plate, tail flick and acetic acid writhing tests. ET-1 (0.625-5 pmol/mouse) and ET-3 (2.5-25 pmol/mouse) produced statistically significant increase of the hot plate and tail flick latencies with duration of about 120 min. ET-3 showed weaker antinociceptive effect. ET-1 inhibited acetic acid-induced writhings with ED50 = 1.9 (1.1-2.7) pmol/mouse. With ET-3 a maximum effect of 45.2% suppression of the writhing response was achieved at 5 pmol/mouse. The antinociception due to ET-1 and ET-3 was not antagonized by naloxone and is thus independent of endogenous opioid release.

AB - The antinociceptive effects of centrally administered (i.c.v.) endothelin- 1 (ET-1) and endothelin-3 (ET-3) were studied in mice by the use of 3 experimental procedures: hot plate, tail flick and acetic acid writhing tests. ET-1 (0.625-5 pmol/mouse) and ET-3 (2.5-25 pmol/mouse) produced statistically significant increase of the hot plate and tail flick latencies with duration of about 120 min. ET-3 showed weaker antinociceptive effect. ET-1 inhibited acetic acid-induced writhings with ED50 = 1.9 (1.1-2.7) pmol/mouse. With ET-3 a maximum effect of 45.2% suppression of the writhing response was achieved at 5 pmol/mouse. The antinociception due to ET-1 and ET-3 was not antagonized by naloxone and is thus independent of endogenous opioid release.

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