Antioxidant activity of ubiquinone-3 in human low density lipoprotein

Giuliana Merati, Petronio Pasquali, Carlo Vergani, Laura Landi

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of ubiquinone-3, a short chain ubiquinone homologue, to prevent Cu2+ induced oxidation of human low density lipoprotein was investigated. The results are as follows: in the presence of ubiquinone-3 the extent of peroxidation, as determined by the formation of thiobarbituric acid reactive substances, was only one third of that found in its absence; the quinone can also prevent the fragmentation of apolipo-protein B-100 and the increase of the net negative surface charge of the particle.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalFree Radical Research
Volume16
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • Antioxidant
  • Apolipoprotein B-100
  • Low density lipoprotein
  • Ubiquinone

ASJC Scopus subject areas

  • Biochemistry

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