Abstract
Background - Free radical production has been reported to be increased in patients with diabetes mellitus, and it has been suggested that hyperglycaemia may directly contribute to the generation of oxidative stress. The aim of the present study was to evaluate the effects of an acute increase in glycaemia on plasma antioxidant defences. Results - During the oral glucose tolerance test (OGTT), plasma concentration of protein-bound sulphydryl (SH) groups, vitamin C, vitamin E and uric acid significantly decreased in normal as well as non-insulin-dependent diabetes mellitus (NIDDM) subjects. Total plasma radical-trapping activity, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual co-operation, was also significantly reduced. Conclusion - This finding supports the hypothesis that hyperglycaemia may, even acutely, induce an oxidative stress.
| Original language | English |
|---|---|
| Pages (from-to) | 329-333 |
| Number of pages | 5 |
| Journal | European Journal of Clinical Investigation |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- Acute hyperglycaemia
- Antioxidants
- Diabetes
- Oral glucose tolerance test
- Oxidative stress
- Total radical-trapping antioxidant parameter
ASJC Scopus subject areas
- Medicine(all)
Cite this
Antioxidant defences are reduced during the oral glucose tolerance test in normal and non-insulin-dependent diabetic subjects. / Ceriello, A.; Bortolotti, N.; Crescentini, A.; Motz, E.; Lizzio, S.; Russo, A.; Ézsol, Z.; Tonutti, L.; Taboga, C.
In: European Journal of Clinical Investigation, Vol. 28, No. 4, 1998, p. 329-333.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antioxidant defences are reduced during the oral glucose tolerance test in normal and non-insulin-dependent diabetic subjects
AU - Ceriello, A.
AU - Bortolotti, N.
AU - Crescentini, A.
AU - Motz, E.
AU - Lizzio, S.
AU - Russo, A.
AU - Ézsol, Z.
AU - Tonutti, L.
AU - Taboga, C.
PY - 1998
Y1 - 1998
N2 - Background - Free radical production has been reported to be increased in patients with diabetes mellitus, and it has been suggested that hyperglycaemia may directly contribute to the generation of oxidative stress. The aim of the present study was to evaluate the effects of an acute increase in glycaemia on plasma antioxidant defences. Results - During the oral glucose tolerance test (OGTT), plasma concentration of protein-bound sulphydryl (SH) groups, vitamin C, vitamin E and uric acid significantly decreased in normal as well as non-insulin-dependent diabetes mellitus (NIDDM) subjects. Total plasma radical-trapping activity, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual co-operation, was also significantly reduced. Conclusion - This finding supports the hypothesis that hyperglycaemia may, even acutely, induce an oxidative stress.
AB - Background - Free radical production has been reported to be increased in patients with diabetes mellitus, and it has been suggested that hyperglycaemia may directly contribute to the generation of oxidative stress. The aim of the present study was to evaluate the effects of an acute increase in glycaemia on plasma antioxidant defences. Results - During the oral glucose tolerance test (OGTT), plasma concentration of protein-bound sulphydryl (SH) groups, vitamin C, vitamin E and uric acid significantly decreased in normal as well as non-insulin-dependent diabetes mellitus (NIDDM) subjects. Total plasma radical-trapping activity, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual co-operation, was also significantly reduced. Conclusion - This finding supports the hypothesis that hyperglycaemia may, even acutely, induce an oxidative stress.
KW - Acute hyperglycaemia
KW - Antioxidants
KW - Diabetes
KW - Oral glucose tolerance test
KW - Oxidative stress
KW - Total radical-trapping antioxidant parameter
UR - http://www.scopus.com/inward/record.url?scp=0031977246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031977246&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2362.1998.00295.x
DO - 10.1046/j.1365-2362.1998.00295.x
M3 - Article
C2 - 9615913
AN - SCOPUS:0031977246
VL - 28
SP - 329
EP - 333
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
SN - 0014-2972
IS - 4
ER -