Antioxidant effect of flavonoids

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Our body generates hydroxyl radicals under a number of conditions. This radical is very unstable and, therefore, very reactive. After attack of radicals on membranes and lipoproteins, lipid peroxidation starts, and may lead to the development of vascular lesions. The human body has developed antioxidant defenses to protect against free radicals such as superoxide dismutases, glutathione peroxidases, plasma iron binding proteins, or α tocopherol. Oxidized LDL are believed to play a key role in vascular damage and can modulate several endothelial properties including NO production and expression of adhesion molecules. Antioxidants, such as flavonoids, inhibit 'in vitro' oxidation of LDL and their cytotoxicity; in humans consumption of flavonoids appears to be related to a reduction of the risk of cardiovascular diseases. The biochemical mechanisms responsible for this effect remain to be addressed.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalAngiology
Volume48
Issue number1
Publication statusPublished - 1997

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Flavonoids
Blood Vessels
Antioxidants
Iron-Binding Proteins
Tocopherols
Risk Reduction Behavior
Membrane Lipids
Glutathione Peroxidase
Human Body
Hydroxyl Radical
Lipid Peroxidation
Lipoproteins
Superoxide Dismutase
Free Radicals
Blood Proteins
Cardiovascular Diseases
oxidized low density lipoprotein
In Vitro Techniques

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Antioxidant effect of flavonoids. / Catapano, Alberico L.

In: Angiology, Vol. 48, No. 1, 1997, p. 39-44.

Research output: Contribution to journalArticle

Catapano, AL 1997, 'Antioxidant effect of flavonoids', Angiology, vol. 48, no. 1, pp. 39-44.
Catapano, Alberico L. / Antioxidant effect of flavonoids. In: Angiology. 1997 ; Vol. 48, No. 1. pp. 39-44.
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