TY - JOUR
T1 - Antioxidant enzyme activities in healthy old subjects
T2 - Influence of age, gender and zinc status: Results from the Zincage Project
AU - Mariani, E.
AU - Cornacchiola, V.
AU - Polidori, M. C.
AU - Mangialasche, F.
AU - Malavolta, M.
AU - Cecchetti, R.
AU - Bastiani, P.
AU - Baglioni, M.
AU - Mocchegiani, E.
AU - Mecocci, P.
PY - 2006/10
Y1 - 2006/10
N2 - Enzymatic activities of plasma superoxide dismutase (pSOD), catalase (CAT) and glutathione peroxidase (GPx) and erythrocyte superoxide dismutase (eSOD) were assayed in 981 healthy community dwelling old subjects participating in the Zincage Project. The relationship between antioxidant enzyme activities and, respectively, gender, age and zinc status were assessed. eSOD activity was higher in nonagenarians than in 80 year old subjects. Plasma Zn was lower in nonagenarians compared with younger subjects. The prevalence of Zn deficiency increased with age, with normal Zn levels observed in about 80% of adult subjects and only in 37% of the nonagenarians. Women showed higher eSOD and CAT activities compared to men, whereas plasma Zn was higher in men than in women. There was a positive correlation between eSOD activity and age and a negative correlation between eSOD activity and plasma Zn concentrations. An inverse correlation was also found between plasma Zn concentration and age. Further studies on different aspects of Zn metabolism-intake, plasma concentration, peripheral cell concentration, activity and amount of Zn-dependent enzymes-are warranted.
AB - Enzymatic activities of plasma superoxide dismutase (pSOD), catalase (CAT) and glutathione peroxidase (GPx) and erythrocyte superoxide dismutase (eSOD) were assayed in 981 healthy community dwelling old subjects participating in the Zincage Project. The relationship between antioxidant enzyme activities and, respectively, gender, age and zinc status were assessed. eSOD activity was higher in nonagenarians than in 80 year old subjects. Plasma Zn was lower in nonagenarians compared with younger subjects. The prevalence of Zn deficiency increased with age, with normal Zn levels observed in about 80% of adult subjects and only in 37% of the nonagenarians. Women showed higher eSOD and CAT activities compared to men, whereas plasma Zn was higher in men than in women. There was a positive correlation between eSOD activity and age and a negative correlation between eSOD activity and plasma Zn concentrations. An inverse correlation was also found between plasma Zn concentration and age. Further studies on different aspects of Zn metabolism-intake, plasma concentration, peripheral cell concentration, activity and amount of Zn-dependent enzymes-are warranted.
KW - Aging
KW - Catalase
KW - Glutathione peroxidase
KW - Oxidative stress
KW - Superoxide dismutase
KW - Zinc
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U2 - 10.1007/s10522-006-9054-6
DO - 10.1007/s10522-006-9054-6
M3 - Article
C2 - 16967205
AN - SCOPUS:34248230381
VL - 7
SP - 391
EP - 398
JO - Biogerontology
JF - Biogerontology
SN - 1389-5729
IS - 5-6
ER -