Antioxidant enzymes in erythrocytes from old and diet restricted old rats.

C. Pieri, M. Falasca, F. Moroni, R. Recchioni, F. Marcheselli, C. Ioppolo, F. Marmocchi

Research output: Contribution to journalArticlepeer-review


Diet restriction, prolonging the lifespan of rodents, represents an interesting model for gerontological studies. We analyzed the activity of antioxidant enzymes, Superoxide Dismutase, Catalase and Glutathione Peroxidase in erythrocytes from young, old and old food restricted Wistar rats. Diet restriction was applied feeding the animals on every-other-day schedule starting from the age of 3.5 months. The age-dependent decrease of Catalase and Glutathione Peroxidase activities was prevented by food restriction, whereas Superoxide Dismutase activity was not influenced either by aging and dietary intervention. Present results support the hypothesis that diet restriction increases the protection of cell structure against the peroxidative damage, preserving the activity of antioxidant enzymes.

Original languageEnglish
Pages (from-to)909-914
Number of pages6
JournalBollettino della Societa Italiana di Biologia Sperimentale
Issue number10
Publication statusPublished - Oct 1990

ASJC Scopus subject areas

  • Medicine(all)


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