Antioxidant profile and early outcome in stroke patients

Antonio Cherubini, Maria Cristina Polidori, Mario Bregnocchi, Salvatore Pezzuto, Roberta Cecchetti, Tiziana Ingegni, Angelo Di Iorio, Umberto Senin, Patrizia Mecocci

Research output: Contribution to journalArticle

Abstract

Background and Purpose - Experimental studies provide evidence of an association between ischemic stroke and increased oxidative stress, but data in humans are still limited and controversial. The purpose of this study was to investigate the time course of plasma antioxidant changes in ischemic stroke patients. Methods - Plasma antioxidants, including water-soluble (vitamin C and uric acid) and lipid-soluble (vitamins A and E) compounds as well as antioxidant enzyme activities in plasma (superoxide dismutase [SOD] and glutathione peroxidase) and erythrocytes (SOD), were measured by high-performance liquid chromatography (antioxidant vitamins) and by spectrophotometry (antioxidant enzymes) in 38 subjects (25 men and 13 women aged 77.2±7.9 years) with acute ischemic stroke of recent onset (

Original languageEnglish
Pages (from-to)2295-2300
Number of pages6
JournalStroke
Volume31
Issue number10
Publication statusPublished - 2000

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Keywords

  • Antioxidants
  • Outcome
  • Oxidative stress
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Cherubini, A., Polidori, M. C., Bregnocchi, M., Pezzuto, S., Cecchetti, R., Ingegni, T., Di Iorio, A., Senin, U., & Mecocci, P. (2000). Antioxidant profile and early outcome in stroke patients. Stroke, 31(10), 2295-2300.