Antioxidant profile and early outcome in stroke patients

Antonio Cherubini; Maria Cristina Polidori; Mario Bregnocchi; Salvatore Pezzuto; Roberta Cecchetti; Tiziana Ingegni; Angelo Di Iorio; Umberto Senin; Patrizia Mecocci

Antioxidant profile and early outcome in stroke patients

Antonio Cherubini, Maria Cristina Polidori, Mario Bregnocchi, Salvatore Pezzuto, Roberta Cecchetti, Tiziana Ingegni, Angelo Di Iorio, Umberto Senin, Patrizia Mecocci

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Purpose - Experimental studies provide evidence of an association between ischemic stroke and increased oxidative stress, but data in humans are still limited and controversial. The purpose of this study was to investigate the time course of plasma antioxidant changes in ischemic stroke patients. Methods - Plasma antioxidants, including water-soluble (vitamin C and uric acid) and lipid-soluble (vitamins A and E) compounds as well as antioxidant enzyme activities in plasma (superoxide dismutase [SOD] and glutathione peroxidase) and erythrocytes (SOD), were measured by high-performance liquid chromatography (antioxidant vitamins) and by spectrophotometry (antioxidant enzymes) in 38 subjects (25 men and 13 women aged 77.2±7.9 years) with acute ischemic stroke of recent onset (

Original language	English
Pages (from-to)	2295-2300
Number of pages	6
Journal	Stroke
Volume	31
Issue number	10
Publication status	Published - 2000

Keywords

Antioxidants
Outcome
Oxidative stress
Stroke

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Neuroscience(all)

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AU - Cherubini, Antonio

AU - Polidori, Maria Cristina

AU - Bregnocchi, Mario

AU - Pezzuto, Salvatore

AU - Cecchetti, Roberta

AU - Ingegni, Tiziana

AU - Di Iorio, Angelo

AU - Senin, Umberto

AU - Mecocci, Patrizia

PY - 2000

Y1 - 2000

N2 - Background and Purpose - Experimental studies provide evidence of an association between ischemic stroke and increased oxidative stress, but data in humans are still limited and controversial. The purpose of this study was to investigate the time course of plasma antioxidant changes in ischemic stroke patients. Methods - Plasma antioxidants, including water-soluble (vitamin C and uric acid) and lipid-soluble (vitamins A and E) compounds as well as antioxidant enzyme activities in plasma (superoxide dismutase [SOD] and glutathione peroxidase) and erythrocytes (SOD), were measured by high-performance liquid chromatography (antioxidant vitamins) and by spectrophotometry (antioxidant enzymes) in 38 subjects (25 men and 13 women aged 77.2±7.9 years) with acute ischemic stroke of recent onset (

AB - Background and Purpose - Experimental studies provide evidence of an association between ischemic stroke and increased oxidative stress, but data in humans are still limited and controversial. The purpose of this study was to investigate the time course of plasma antioxidant changes in ischemic stroke patients. Methods - Plasma antioxidants, including water-soluble (vitamin C and uric acid) and lipid-soluble (vitamins A and E) compounds as well as antioxidant enzyme activities in plasma (superoxide dismutase [SOD] and glutathione peroxidase) and erythrocytes (SOD), were measured by high-performance liquid chromatography (antioxidant vitamins) and by spectrophotometry (antioxidant enzymes) in 38 subjects (25 men and 13 women aged 77.2±7.9 years) with acute ischemic stroke of recent onset (

KW - Antioxidants

KW - Outcome

KW - Oxidative stress

KW - Stroke

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Antioxidant profile and early outcome in stroke patients

Abstract

Keywords

ASJC Scopus subject areas

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