Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia

Giancarlo Zito, Renato Polimanti, Valentina Panetta, Mariacarla Ventriglia, Carlo Salustri, Maria Cristina Siotto, Filomena Moffa, Claudia Altamura, Fabrizio Vernieri, Domenico Lupoi, Emanuele Cassetta, Paolo M. Rossini, Rosanna Squitti

Research output: Contribution to journalArticle

Abstract

Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the ε4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis may elucidate the causes of neurodegenerative processes. To address this issue, we evaluated the effects of antioxidant status and APOE genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls. Eighty-two AD, 42 VaD patients, and 26 healthy controls were recruited and underwent medial temporal lobe atrophy (MTA) assessment, white matter hyperintensities rating (WMH), serum total antioxidant status assaying (TAS), and APOE genotyping. A logistic regression algorithm applied to our data revealed that a 0.01 mmol/L decrease of TAS concentration increased the probability of MTA by 24% (p=0.038) and that carriers of the APOE ε4 allele showed higher WMH scores (p=0.018), confirming that small variations in antioxidant systems homeostasis are associated with relevant modifications of disease risk. Furthermore, in individuals with analogous TAS values, the presence of the ε4 allele increased the predicted probability of having MTA. These outcomes further sustain the interaction of oxidative stress and APOE genotype to neurodegeneration.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalRejuvenation Research
Volume16
Issue number1
DOIs
Publication statusPublished - Feb 1 2013

Fingerprint

Vascular Dementia
Alzheimer Disease
Antioxidants
Genotype
Temporal Lobe
Atrophy
Alleles
Neurodegenerative Diseases
Oxidative Stress
Apolipoprotein E4
Lipid Metabolism
Dementia
Homeostasis
Logistic Models
Lipids
Serum

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia. / Zito, Giancarlo; Polimanti, Renato; Panetta, Valentina; Ventriglia, Mariacarla; Salustri, Carlo; Siotto, Maria Cristina; Moffa, Filomena; Altamura, Claudia; Vernieri, Fabrizio; Lupoi, Domenico; Cassetta, Emanuele; Rossini, Paolo M.; Squitti, Rosanna.

In: Rejuvenation Research, Vol. 16, No. 1, 01.02.2013, p. 51-56.

Research output: Contribution to journalArticle

Zito, G, Polimanti, R, Panetta, V, Ventriglia, M, Salustri, C, Siotto, MC, Moffa, F, Altamura, C, Vernieri, F, Lupoi, D, Cassetta, E, Rossini, PM & Squitti, R 2013, 'Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia', Rejuvenation Research, vol. 16, no. 1, pp. 51-56. https://doi.org/10.1089/rej.2012.1383
Zito, Giancarlo ; Polimanti, Renato ; Panetta, Valentina ; Ventriglia, Mariacarla ; Salustri, Carlo ; Siotto, Maria Cristina ; Moffa, Filomena ; Altamura, Claudia ; Vernieri, Fabrizio ; Lupoi, Domenico ; Cassetta, Emanuele ; Rossini, Paolo M. ; Squitti, Rosanna. / Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia. In: Rejuvenation Research. 2013 ; Vol. 16, No. 1. pp. 51-56.
@article{6b463bf1e66646028a60074d92f2d17e,
title = "Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia",
abstract = "Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the ε4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis may elucidate the causes of neurodegenerative processes. To address this issue, we evaluated the effects of antioxidant status and APOE genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls. Eighty-two AD, 42 VaD patients, and 26 healthy controls were recruited and underwent medial temporal lobe atrophy (MTA) assessment, white matter hyperintensities rating (WMH), serum total antioxidant status assaying (TAS), and APOE genotyping. A logistic regression algorithm applied to our data revealed that a 0.01 mmol/L decrease of TAS concentration increased the probability of MTA by 24{\%} (p=0.038) and that carriers of the APOE ε4 allele showed higher WMH scores (p=0.018), confirming that small variations in antioxidant systems homeostasis are associated with relevant modifications of disease risk. Furthermore, in individuals with analogous TAS values, the presence of the ε4 allele increased the predicted probability of having MTA. These outcomes further sustain the interaction of oxidative stress and APOE genotype to neurodegeneration.",
author = "Giancarlo Zito and Renato Polimanti and Valentina Panetta and Mariacarla Ventriglia and Carlo Salustri and Siotto, {Maria Cristina} and Filomena Moffa and Claudia Altamura and Fabrizio Vernieri and Domenico Lupoi and Emanuele Cassetta and Rossini, {Paolo M.} and Rosanna Squitti",
year = "2013",
month = "2",
day = "1",
doi = "10.1089/rej.2012.1383",
language = "English",
volume = "16",
pages = "51--56",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",
number = "1",

}

TY - JOUR

T1 - Antioxidant status and APOE genotype as susceptibility factors for neurodegeneration in alzheimer's disease and vascular dementia

AU - Zito, Giancarlo

AU - Polimanti, Renato

AU - Panetta, Valentina

AU - Ventriglia, Mariacarla

AU - Salustri, Carlo

AU - Siotto, Maria Cristina

AU - Moffa, Filomena

AU - Altamura, Claudia

AU - Vernieri, Fabrizio

AU - Lupoi, Domenico

AU - Cassetta, Emanuele

AU - Rossini, Paolo M.

AU - Squitti, Rosanna

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the ε4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis may elucidate the causes of neurodegenerative processes. To address this issue, we evaluated the effects of antioxidant status and APOE genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls. Eighty-two AD, 42 VaD patients, and 26 healthy controls were recruited and underwent medial temporal lobe atrophy (MTA) assessment, white matter hyperintensities rating (WMH), serum total antioxidant status assaying (TAS), and APOE genotyping. A logistic regression algorithm applied to our data revealed that a 0.01 mmol/L decrease of TAS concentration increased the probability of MTA by 24% (p=0.038) and that carriers of the APOE ε4 allele showed higher WMH scores (p=0.018), confirming that small variations in antioxidant systems homeostasis are associated with relevant modifications of disease risk. Furthermore, in individuals with analogous TAS values, the presence of the ε4 allele increased the predicted probability of having MTA. These outcomes further sustain the interaction of oxidative stress and APOE genotype to neurodegeneration.

AB - Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the ε4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis may elucidate the causes of neurodegenerative processes. To address this issue, we evaluated the effects of antioxidant status and APOE genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls. Eighty-two AD, 42 VaD patients, and 26 healthy controls were recruited and underwent medial temporal lobe atrophy (MTA) assessment, white matter hyperintensities rating (WMH), serum total antioxidant status assaying (TAS), and APOE genotyping. A logistic regression algorithm applied to our data revealed that a 0.01 mmol/L decrease of TAS concentration increased the probability of MTA by 24% (p=0.038) and that carriers of the APOE ε4 allele showed higher WMH scores (p=0.018), confirming that small variations in antioxidant systems homeostasis are associated with relevant modifications of disease risk. Furthermore, in individuals with analogous TAS values, the presence of the ε4 allele increased the predicted probability of having MTA. These outcomes further sustain the interaction of oxidative stress and APOE genotype to neurodegeneration.

UR - http://www.scopus.com/inward/record.url?scp=84874279735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874279735&partnerID=8YFLogxK

U2 - 10.1089/rej.2012.1383

DO - 10.1089/rej.2012.1383

M3 - Article

C2 - 23216585

AN - SCOPUS:84874279735

VL - 16

SP - 51

EP - 56

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

IS - 1

ER -