Antioxidant vitamins reduce oxidative stress and ventricular remodeling in patients with acute myocardial infarction

C. Gasparetto, A. Malinverno, D. Culacciati, D. Gritti, P. G. Prosperini, G. Specchia, Giovanni Ricevuti

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed soluble vascular adhesion molecules (SVCAM-1), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-1 serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-1 (P) vs sVCAM -1(AT) was 2.03±0.5 vs 1.63±0.7 μg/ml with p

Original languageEnglish
Pages (from-to)487-496
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume18
Issue number3
Publication statusPublished - Jul 2005

Keywords

  • Acute myocardial infarction
  • Antioxidant vitamins
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology

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