TY - JOUR
T1 - Antioxidant vitamins reduce oxidative stress and ventricular remodeling in patients with acute myocardial infarction
AU - Gasparetto, C.
AU - Malinverno, A.
AU - Culacciati, D.
AU - Gritti, D.
AU - Prosperini, P. G.
AU - Specchia, G.
AU - Ricevuti, Giovanni
PY - 2005/7
Y1 - 2005/7
N2 - We analyzed soluble vascular adhesion molecules (SVCAM-1), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-1 serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-1 (P) vs sVCAM -1(AT) was 2.03±0.5 vs 1.63±0.7 μg/ml with p
AB - We analyzed soluble vascular adhesion molecules (SVCAM-1), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-1 serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-1 (P) vs sVCAM -1(AT) was 2.03±0.5 vs 1.63±0.7 μg/ml with p
KW - Acute myocardial infarction
KW - Antioxidant vitamins
KW - Oxidative stress
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M3 - Article
C2 - 16164829
AN - SCOPUS:27444441151
VL - 18
SP - 487
EP - 496
JO - International Journal of Immunopathology and Pharmacology
JF - International Journal of Immunopathology and Pharmacology
SN - 0394-6320
IS - 3
ER -