Antioxidant vitamins reduce oxidative stress and ventricular remodeling in patients with acute myocardial infarction

C. Gasparetto; A. Malinverno; D. Culacciati; D. Gritti; P. G. Prosperini; G. Specchia; Giovanni Ricevuti

Antioxidant vitamins reduce oxidative stress and ventricular remodeling in patients with acute myocardial infarction

C. Gasparetto, A. Malinverno, D. Culacciati, D. Gritti, P. G. Prosperini, G. Specchia, Giovanni Ricevuti

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

We analyzed soluble vascular adhesion molecules (_SVCAM-1), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-1 serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-1 (P) vs sVCAM -1(AT) was 2.03±0.5 vs 1.63±0.7 μg/ml with p

Original language	English
Pages (from-to)	487-496
Number of pages	10
Journal	International Journal of Immunopathology and Pharmacology
Volume	18
Issue number	3
Publication status	Published - Jul 2005

Keywords

Acute myocardial infarction
Antioxidant vitamins
Oxidative stress

ASJC Scopus subject areas

Pharmacology

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Antioxidant vitamins reduce oxidative stress and ventricular remodeling in patients with acute myocardial infarction. / Gasparetto, C.; Malinverno, A.; Culacciati, D.; Gritti, D.; Prosperini, P. G.; Specchia, G.; Ricevuti, Giovanni.

In: International Journal of Immunopathology and Pharmacology, Vol. 18, No. 3, 07.2005, p. 487-496.

Research output: Contribution to journal › Article › peer-review

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abstract = "We analyzed soluble vascular adhesion molecules (SVCAM-1), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-1 serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-1 (P) vs sVCAM -1(AT) was 2.03±0.5 vs 1.63±0.7 μg/ml with p",

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AU - Gasparetto, C.

AU - Malinverno, A.

AU - Culacciati, D.

AU - Gritti, D.

AU - Prosperini, P. G.

AU - Specchia, G.

AU - Ricevuti, Giovanni

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Antioxidant vitamins reduce oxidative stress and ventricular remodeling in patients with acute myocardial infarction

Abstract

Keywords

ASJC Scopus subject areas

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