Abstract
With an ever increasing aging population, age-related neurodegenerative disorders such as stroke and Alzheimer's disease (AD) are a major health concern in our society. AD is a debilitating disease affecting more than 35 million individuals worldwide, a figure that is expected to increase to over 115 million by 2050 (Rosamond et al. 2008). Similarly, stroke is the second leading cause of death in the world occurring in middle-aged and the elderly. According to the World Health Organization (WHO) estimations in 2005, stroke accounted for 5.7 million deaths worldwide, equivalent to 9.9 % of all deaths. The pathogenesis of neurodegenerative disorders is often complex and includes a number of features such as a genetic disposition as well as common causative factors that include aging, excitotoxicity, inflammation, as well as oxidative stress. Although a lot of progress has been made in the understanding of brain disease pathogenesis, unfortunately therapies are far from being effective. In this chapter, the contribution of oxidative stress to the pathogenesis of neurodegeneration will be discussed.
| Original language | English |
|---|---|
| Title of host publication | Systems Biology of Free Radicals and Antioxidants |
| Publisher | Springer-Verlag Berlin Heidelberg |
| Pages | 2175-2189 |
| Number of pages | 15 |
| ISBN (Print) | 9783642300189, 3642300170, 9783642300172 |
| DOIs | |
| Publication status | Published - May 1 2012 |
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Keywords
- Alzheimer's disease
- Antioxidants
- ROS
- Stroke
ASJC Scopus subject areas
- Medicine(all)
Cite this
Antioxidants and neuroprotection. / Antoniou, Xanthi; Borsello, Tiziana; Lüscher, Thomas F.; Camici, Giovanni G.
Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, 2012. p. 2175-2189.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Antioxidants and neuroprotection
AU - Antoniou, Xanthi
AU - Borsello, Tiziana
AU - Lüscher, Thomas F.
AU - Camici, Giovanni G.
PY - 2012/5/1
Y1 - 2012/5/1
N2 - With an ever increasing aging population, age-related neurodegenerative disorders such as stroke and Alzheimer's disease (AD) are a major health concern in our society. AD is a debilitating disease affecting more than 35 million individuals worldwide, a figure that is expected to increase to over 115 million by 2050 (Rosamond et al. 2008). Similarly, stroke is the second leading cause of death in the world occurring in middle-aged and the elderly. According to the World Health Organization (WHO) estimations in 2005, stroke accounted for 5.7 million deaths worldwide, equivalent to 9.9 % of all deaths. The pathogenesis of neurodegenerative disorders is often complex and includes a number of features such as a genetic disposition as well as common causative factors that include aging, excitotoxicity, inflammation, as well as oxidative stress. Although a lot of progress has been made in the understanding of brain disease pathogenesis, unfortunately therapies are far from being effective. In this chapter, the contribution of oxidative stress to the pathogenesis of neurodegeneration will be discussed.
AB - With an ever increasing aging population, age-related neurodegenerative disorders such as stroke and Alzheimer's disease (AD) are a major health concern in our society. AD is a debilitating disease affecting more than 35 million individuals worldwide, a figure that is expected to increase to over 115 million by 2050 (Rosamond et al. 2008). Similarly, stroke is the second leading cause of death in the world occurring in middle-aged and the elderly. According to the World Health Organization (WHO) estimations in 2005, stroke accounted for 5.7 million deaths worldwide, equivalent to 9.9 % of all deaths. The pathogenesis of neurodegenerative disorders is often complex and includes a number of features such as a genetic disposition as well as common causative factors that include aging, excitotoxicity, inflammation, as well as oxidative stress. Although a lot of progress has been made in the understanding of brain disease pathogenesis, unfortunately therapies are far from being effective. In this chapter, the contribution of oxidative stress to the pathogenesis of neurodegeneration will be discussed.
KW - Alzheimer's disease
KW - Antioxidants
KW - ROS
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84929136416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929136416&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-30018-9_94
DO - 10.1007/978-3-642-30018-9_94
M3 - Chapter
AN - SCOPUS:84929136416
SN - 9783642300189
SN - 3642300170
SN - 9783642300172
SP - 2175
EP - 2189
BT - Systems Biology of Free Radicals and Antioxidants
PB - Springer-Verlag Berlin Heidelberg
ER -