TY - JOUR
T1 - Antiphase signalling in the neuroendocrine-immune system in healthy humans
AU - Mazzoccoli, Gianluigi
AU - Muscarella, Lucia Anna
AU - Fazio, Vito Michele
AU - Piepoli, Ada
AU - Pazienza, Valerio
AU - Dagostino, Mariangela Pia
AU - Giuliani, Francesco
AU - Polyakova, Victoria O.
AU - Kvetnoy, Igor
PY - 2011/7
Y1 - 2011/7
N2 - Background: Any quantity varying in the spatial-temporal dimension may be considered as a signal. Human lymphocyte cell surface molecules and subsets present circadian variation and this variation may represent a kind of signalling in the neuroendocrine-immune system. We have analyzed the dynamics of variation of specific lymphocyte subsets in healthy humans. Subjects and methods: In our study, lymphocyte subpopulation analyses were performed and cortisol, melatonin, GH and TSH serum levels were measured on blood samples collected every 4. h for 24. hours from eleven healthy men, ages 35-53 years (mean=44 ± 6 SD). Results: A clear circadian rhythm was validated for CD8 and cortisol with acrophase during the day and for CD3, CD4, melatonin, GH and TSH with acrophase at night. Cross-correlation showed that CD3 correlated positively with CD4 (ρ=0.67, P
AB - Background: Any quantity varying in the spatial-temporal dimension may be considered as a signal. Human lymphocyte cell surface molecules and subsets present circadian variation and this variation may represent a kind of signalling in the neuroendocrine-immune system. We have analyzed the dynamics of variation of specific lymphocyte subsets in healthy humans. Subjects and methods: In our study, lymphocyte subpopulation analyses were performed and cortisol, melatonin, GH and TSH serum levels were measured on blood samples collected every 4. h for 24. hours from eleven healthy men, ages 35-53 years (mean=44 ± 6 SD). Results: A clear circadian rhythm was validated for CD8 and cortisol with acrophase during the day and for CD3, CD4, melatonin, GH and TSH with acrophase at night. Cross-correlation showed that CD3 correlated positively with CD4 (ρ=0.67, P
KW - Circadian rhythmicity
KW - Cortisol
KW - GH
KW - Lymphocyte subpopulation
KW - Melatonin
KW - Neuroendocrine-immune system
KW - Signaling
KW - TSH
UR - http://www.scopus.com/inward/record.url?scp=79960386164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960386164&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2011.02.002
DO - 10.1016/j.biopha.2011.02.002
M3 - Article
C2 - 21737229
AN - SCOPUS:79960386164
VL - 65
SP - 275
EP - 279
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
IS - 4
ER -