Antiphase signalling in the neuroendocrine-immune system in healthy humans

Gianluigi Mazzoccoli, Lucia Anna Muscarella, Vito Michele Fazio, Ada Piepoli, Valerio Pazienza, Mariangela Pia Dagostino, Francesco Giuliani, Victoria O. Polyakova, Igor Kvetnoy

Research output: Contribution to journalArticlepeer-review


Background: Any quantity varying in the spatial-temporal dimension may be considered as a signal. Human lymphocyte cell surface molecules and subsets present circadian variation and this variation may represent a kind of signalling in the neuroendocrine-immune system. We have analyzed the dynamics of variation of specific lymphocyte subsets in healthy humans. Subjects and methods: In our study, lymphocyte subpopulation analyses were performed and cortisol, melatonin, GH and TSH serum levels were measured on blood samples collected every 4. h for 24. hours from eleven healthy men, ages 35-53 years (mean=44 ± 6 SD). Results: A clear circadian rhythm was validated for CD8 and cortisol with acrophase during the day and for CD3, CD4, melatonin, GH and TSH with acrophase at night. Cross-correlation showed that CD3 correlated positively with CD4 (ρ=0.67, P

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalBiomedicine and Pharmacotherapy
Issue number4
Publication statusPublished - Jul 2011


  • Circadian rhythmicity
  • Cortisol
  • GH
  • Lymphocyte subpopulation
  • Melatonin
  • Neuroendocrine-immune system
  • Signaling
  • TSH

ASJC Scopus subject areas

  • Pharmacology


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