Antiphospholipid and antiendothelial antibodies

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A lot of attention has recently been paid to antiphospholipid and antiendothelial cell antibodies as serological markers for systemic autoimmune diseases. Antiphospholipid antibodies appear to display a prognostic value for recurrent thrombosis and fetal loss both in a subset of systemic lupus erythematosus and in patients with the primary antiphospholipid syndrome. The range of diagnostic tests for the antiphospholipid syndrome is now becoming larger with the inclusion of assays suitable for identifying antibodies against phospholipids other than cardiolipin and especially against phospholipid-binding proteins. Antiendothelial cell antibodies have been suggested as serological markers for immune-mediated vascular damage. In vitro and in vivo experimental models as well as epidemiological studies seem to support this. However, the assays for their detection still lack standardization.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume111
Issue number4
Publication statusPublished - Dec 1996

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Antiphospholipid Antibodies
Antiphospholipid Syndrome
Phospholipids
Cardiolipins
Routine Diagnostic Tests
Systemic Lupus Erythematosus
Autoimmune Diseases
Blood Vessels
Epidemiologic Studies
Carrier Proteins
Thrombosis
Theoretical Models
Biomarkers
Antibodies
anti-endothelial cell antibody
In Vitro Techniques

Keywords

  • β-glycoprotein I
  • Endothelial cells
  • Phospholipids
  • Thrombosis
  • Vasculitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Antiphospholipid and antiendothelial antibodies. / Meroni, P. L.; Del Papa, N.; Borghi, M. O.

In: International Archives of Allergy and Immunology, Vol. 111, No. 4, 12.1996, p. 320-325.

Research output: Contribution to journalArticle

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