Antiphospholipid antibodies and the endothelium

Pier Luigi Meroni, Elena Raschi, Cinzia Testoni, Angela Tincani, Genesio Balestrieri

Research output: Contribution to journalArticlepeer-review


The interaction between aPL (particularly anti-β2GPI antibodies) and endothelium does represent a potential pathogenetic mechanism for the thrombotic manifestations of the syndrome. The autoantibody-mediated EC activation probably plays a role in sustaining the appearance of a proadhesive, proinflammatory, and procoagulant phenotype. The heterogeneity of the APS clinical manifestations is likely linked to the varied effects that aPL can induce on ECs and to the different functions that ECs display depending on the anatomic localization.

Original languageEnglish
Pages (from-to)587-602
Number of pages16
JournalRheumatic Disease Clinics of North America
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Rheumatology

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