Antiphospholipid antibodies in paediatrics

A. Ravelli, A. Martini, G. R. Burgio

Research output: Contribution to journalArticlepeer-review

Abstract

Antiphospholipid antibodies, i.e. circulating auto-antibodies to negatively charged phospholipids, are mainly observed in patients with systemic lupus erythematosus, but may also occur in individuals who lack evidence of a well-defined systemic disease. Several studies have suggested that they may play a direct role in the pathogenesis of recurrent vascular thrombosis, repeated abortions, and thrombocytopenia (socalled antiphospholipid antibody syndrome), although the mechanism by which this occurs is still poorly understood. The management of patients with antiphospholipid antibody-related thrombosis includes anti-aggregants, anticoagulants, corticosteroids, and cytotoxic drugs, but the optimum treatment is still controversial. Here we review the test systems used to detect antiphospholipid antibodies and their significance in paediatrics.

Original languageEnglish
Pages (from-to)472-479
Number of pages8
JournalEuropean Journal of Pediatrics
Volume153
Issue number7
DOIs
Publication statusPublished - Jul 1994

Keywords

  • Antiphospholipid antibody syndrome Antiphospholipid antibodies Anticardiolipin antibodies
  • Lupus anticoagulant
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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