Antiphospholipid antibody-associated thrombocytopenia in autoimmune diseases

R. Caporali, M. Longhi, F. De Gennaro, M. Di Lauro, R. Carnevale, C. Montecucco

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Anti-phospholipid antibodies (APA) were measured in 88 patients with peripheral thrombocytopenia by an enzyme-linked immunosorbent assay using cardiolipin as antigen. A positive APA test was found in 76% of systemic lupus erythematosus (SLE), in 72% of chronic active hepatitis (CAH), in 23% of idiopathic thrombocytopenic purpura (ITP), and in 6 out of 7 patients with Evans' syndrome. APA were found in all 3 patients with HIV-associated thrombocytopenia as well as in all 5 HIV-positive narcotic addicts with normal platelet count. Negative results were found in 3 cases with pseudo-thromboyctopenia due to cold thromboagglutinins. A significant APA titer, as found in 59% of SLE patients, was observed in 55% of CAH, 12% of ITP, and 5/7 of Evans' syndrome. The prevalence of APA was significantly lower in 22 SLE and 20 CAH control patients without thromocytopenia. Our data suggest that APA are frequently associated with thrombocytopenia in autoimmune diseases other than SLE and may have a direct role in immune mediated platelet destruction.

Original languageEnglish
Pages (from-to)537-339
Number of pages199
JournalMedical Science Research
Issue number10
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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