Antiphospholipid syndrome: Laboratory detection, mechanisms of action and treatment

A. Tripodi, P. G. de Groot, V. Pengo

Research output: Contribution to journalArticlepeer-review


The antiphospholipid syndrome (APS) identifies a condition at increased risk of vascular occlusion and/or pregnancy complications. Patients are defined as having APS if they have at least one clinical (vascular occlusion and/or pregnancy complications) and one laboratory criterion at the same time. The laboratory criteria that define APS are repeated positivity (confirmed 12weeks apart) for lupus anticoagulants and/or antibodies targeted against cardiolipin or β 2-glycoprotein I immobilized on solid surfaces. Over the years, APS has attracted the interest of many medical specialties. The aim of this review is to provide an update on (i) the laboratory criteria that determine the presence of APS, (ii) how the antibodies increase the risk of vascular occlusion and foetal loss and (iii) the treatment of the related clinical events.

Original languageEnglish
Pages (from-to)110-122
Number of pages13
JournalJournal of Internal Medicine
Issue number2
Publication statusPublished - Aug 2011


  • Arterial thromboembolism
  • Foetal loss
  • Laboratory testing
  • Pregnancy complications
  • Venous thromboembolism

ASJC Scopus subject areas

  • Internal Medicine


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